复方鱼腥草颗粒对老年支原体肺炎患者白细胞介素6、血清心肌酶谱及血管内皮生长因子的影响及疗效观察

Clinical efficacy of compound herba Houttuyniae granules used in elderly mycoplasma pneumonia and the change of IL-6, serum myocardial enzymes and vascular endothelial growth gactorand

目的 研究复方鱼腥草颗粒用于老年人支原体肺炎（MP）治疗的效果及对白细胞介素6（IL-6）、血清心肌酶谱、血管内皮生长因子的影响.方法 以80例老年支原体肺炎患者为观察对象,根据治疗方法分为对照组与治疗组各40例.对照组40例给予利巴韦林颗粒治疗,治疗组40例在对照组基础上给予复方鱼腥草颗粒治疗,观察两组治疗效果和药物不良反应,对比治疗前后IL-6、血清心肌酶谱、血管内皮生长因子的变化.结果 治疗7d后,治疗组有效率97.5％,高于对照组的72.5％（χ2=9.804,P＜0.05）;治疗组不良反应发生率为5.0％,显著低于对照组的32.5％（χ2=9.928,P＜0.05）.治疗前两组IL-6、血清心肌酶谱、血管内皮生长因子水平差异均无统计学意义（均P＞0.05）,治疗后治疗组IL-6、血清心肌酶谱、血管内皮生长因子水平均显著低于对照组（均P＜0.05）.结论 复方鱼腥草颗粒对老年人支原体肺炎的治疗效果明显,不良反应发生率低,且有利于临床相关观察指标的改善,可作为治疗老年人支原体肺炎的优选.

Objective To study the clinical efficacy of compound herba Houttuyniae granules used in mycoplasma pneumonia in the elderly and analyze the change of IL-6,serum myocardial enzymes and vascular endothelial growth factor before and after the treatment.Methods According to treatment methods,80 elderly patients with mycoplasma pneumonia,were divided into the control group and treatment group,40 cases in each group,the control group were given Ribavirin granules,the treatment group was given on the basis of the control group and compound herba Houttuyniae granules.The therapeutic effects and the incidence of adverse drug reactions were observed,and the change of IL-6,serum myocardial enzymes and vascular endothelial growth factor of the two groups before and after the treatment were compared.Results After 7-days＆#39;treatment,the efficiency of the treatment group（97.5%） was significantly higher than that of the control group（72.5%） （χ2 =9.804,P 〈0.05）.After the drug treatment,the rate of adverse drug reactions was 5.0% in the treatment group,which was significantly lower than the 32.5% in the control group（χ2 =9.928,P 〈 0.05）.Before treatment,the IL-6,serum myocardial enzymes and vascular endothelial growth factor were not significantly different between the two groups （all P 〉 0.05）.After treatment,the IL-6,serum myocardial enzymes and vascular endothelial growth factor of the treatment group were significantly lower than those of the control group （all P 〈 0.05）.Conclusion The treatment of compound herba Houttuyniae granules used in elderly mycoplasma pneumonia is efficient and the incidence of adverse reactions was low.It can improve the clinically relevant outcome measures and is worthy of clinical application.