5-氨基酮戊酸光动力疗法联合中药治疗面部扁平疣的疗效观察

Clinical Observation on Treatment of Facal Flat Wart by the Combination of 5-ALA-PDT with Chinese Medicine

目的探讨应用5-氨基酮戊酸光动力疗法联合中药治疗面部扁平疣的临床效果。方法回顾性分析2011年5月~2014年1月我院皮肤科收治的123例面部扁平疣患者,应用随机数字分组法分为治疗组和对照组,对照组予以5-氨基酮戊酸光动力梯度疗法,治疗组在对照组的基础上加用中药治疗。结果在治疗2周后治疗组总有效率为95.24%,对照组总有效率为81.67%,两组疗效比较差异具有统计学意义(x^2=5.612,P=0.018);在治疗6周后治疗组总有效率为100%,对照组总有效率为91.67%,两组疗效比较差异具有统计学意义(x^2=5.472,P=0.019);治疗组及对照组复发率分别为3.17%、18.33%,两组疗效比较差异具有统计学意义(P<0.05)。结论 5-氨基酮戊酸光动力疗法联合中药治疗面部扁平疣可缩短疗程,同时可以减少复发率,值得临床借鉴。

Objective： To explore the clinical effect of 5-ALA-PDT （5-aminolevulinic acid photodynamic therapy）combined with Chinese medicine on patients with facial flat wart. Methods： From May 2011 to January 2014, the 123 patients with facial flat wart in our hospital were retrospectively analyzed and divided into Chinese medical group and cantrol group by random number table method. The control group were given 5-ALA-PDT, with which Chinese medicine combined were prescribed to the cases of Chinese medical group. Results： After 2 weeks treatment, the total effective rate of Chinese medical group was 95.24 %, while that of control group 81.67 % and its difference between the two groups showed statistical meanings （x^2 =5. 612 ,P= 0.018）; after 6 weeks treatment, the total effective rate of Chinese medical group was 100 %, while that of control group 91.67 % and its difference between the two groups had statistical meanings （x^2= 5. 472,P = 0.019 ） ; the reoccurrence rates of the medical and control groups were respectively 3.17 % and 18.33 %, the difference between the two groups showed statistical meanings （P〈0.05）. Conclusion： The combina- tion of 5-ALA-PDT with Chinese medicine for facial flat wart not just shorten the therapeutic duration, but decrease its reoccurrence rates, worthy of our reference.