氯胺酮对阴式子宫肌瘤剔除患者术中炎症因子水平的影响被引量：2

Effects of Ketamine on Inflammatory Cytokines in Patients Undergoing Transvaginal Myomectomy

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摘要目的探讨氯胺酮对阴式子宫肌瘤剔除患者术中血清炎症因子水平的影响。方法择期阴式子宫肌瘤剔除术的全麻患者60例,随机分为对照组(C组)和氯胺酮组(K组),每组30例。分别在患者入室时(T0)、麻醉诱导后(T1)、手术开始后60min(T2)和手术结束时(T3)四个时间点采集外周静脉血,检测患者血清白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的浓度。结果两组患者在T0、T1时刻的血清IL-6、TNF-α浓度差异无统计学意义(P>0.05),K组在T2、T3时刻的血清IL-6、TNF-α浓度均明显更低,差异有统计学意义(P<0.05)。结论氯胺酮能有效抑制阴式子宫肌瘤剔除患者术中IL-6、TNF-α的释放,减轻术中炎症反应。 Objective To investigate the effects of ketamine on serum levels of inflammatory cytokines during the periop- erative period in patients undergoing transvaginal myomectomy. Methods 60 patients undergoing transvaginal myomectomy with general anesthesia, were randomly assigned to the control group （group C） or ketamine group （group K）, 30 cases in each group. The venous blood samples were taken from the patients at four time points respectively： when patients to enter the operating room （ To, baseline）, after induction of anesthesia （ T1 ）, 60min after operation （ T2 ） and the end of operation （ T3 ）, detection of ser- um interleukin-6 （IL-6） and tumor necrosis factor-a （TNF-α） concentrations. Results At the To and T1 time points, there was no significant difference in serum concentrations of IL-6 and TNF-α between group C and group K （P 〉 0. 05 ）, at the T2, T 3 time points, group K exhibited significantly lower serum concentrations of IL-6 and TNF-α in comparison with group C （P 〈 0. 05 ）. Conclusion Ketamine can effectively reduce the release of IL-6 and TNF-α in patients undergoing transvaginal myomectomy and alleviate the intraoperative inflammatory response.

作者刘晓彬吴爱玲李健

机构地区郫县人民医院麻醉科内江市第一人民医院

出处《四川医学》 CAS 2015年第5期642-645,共4页 Sichuan Medical Journal

关键词氯胺酮阴式子宫肌瘤剔除术炎症介质 ketamine transvaginal myomectomy inflammatory cytokines

分类号 R737.33 [医药卫生—肿瘤] R614 [医药卫生—麻醉学]

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