血清胱抑素C检测在老年慢性肾功能衰竭诊断中的意义

Serum Cystatin C detection in the diagnosis of senile chronic renal failure significance

目的探讨检测血清胱抑素C(Cys-C)在老年慢性肾功能衰竭诊断中的临床意义。方法采用胶乳增强免疫比浊法在新成生物XC8001全自动生化分析仪上检测血清样本中Cys-C的浓度,同时还检测与肾功能密切相关的血清学指标尿素(UREA)、尿酸(UA)和肌酐(CREA)浓度水平。结果老年慢性肾功能衰竭患者血清样本中Cys-C、UREA、UA和CREA的浓度明显高于对照组,两者比较差异有统计学意义P<0.05;老年慢性肾功能衰竭的Ⅱ、Ⅲ、Ⅳ期患者血清中Cys-C的浓度明显高于Ⅰ期,与Ⅰ期比较差异有统计学意义P<0.05。结论血清Cys-C浓度检测可作为老年慢性肾功能衰竭早期判断病情轻重的重要指标,其浓度水平能为老年慢性肾功能衰竭的临床早期诊断、治疗和预后提供参考依据。

Objective Explore detection serum Cystatin C （ Cys - C） in the diagnosis of senile chronic renal failure clin- ical significance. Methods The latex enhanced immune turbidimetric method is adopted on the XC8001 automatic biochemical analyzer on the detection of serum Cys-C concentration in the sample, and also test and serological indexes of renal function is closely related to the UREA （UREA）, uric acid （UA） and creatinine （CREA） levels. Results In elderly patients with chronic renal failure Cys-C, UREA, UA in the serum samples and CREA concentration significantly higher than the control group, the two comparative differences are statistically significant or highly significant （P 〈 0.05 or P 〈 0. 01 ） ; Ⅱ of senile chronic renal failure stage, Ⅲ, Ⅳ patients serum Cys-C concentration significantly higher than the I period, compared with I phase difference is there is statistical significance （P 〈 0. 05 ）. Conclusion Concentration of serum Cys-C early detection can be used as elderly chronic renal failure of important indexes that illness weight, their concentration levels for the elderly with chronic renal failure clinical provide reference basis for early diagnosis, treatment and prognosis.