期刊文献+

原发性高血压并左心室肥厚与基质金属蛋白酶及其组织抑制因子的关系 被引量:4

Relationship of Matrix Metalloproteinases and the Tissue Inhibitor with Left Ventricular Hypertrophy in Patients with Primary Hypertension
下载PDF
导出
摘要 目的探讨原发性高血压患者慢性压力负荷致左心室肥厚与基质金属蛋白酶3(MMP-3)、基质金属蛋白酶9(MMP-9)及金属蛋白酶组织抑制因子1(TIMP-1)血清水平的关系。方法收集原发性高血压患者140例,健康对照组132例,测定MMP-3、MMP-9和TIMP-1;行心脏彩超检查并计算左室重量指数(LVMI)。结果高血压组LVMI升高[(113.7±9.9)vs(88.3±10.4),P<0.001)],MMP-3、MMP-9和TIMP-1增高[(488.32±100.32 vs 314.59±99.78;340.56±43.21 vs 290.15±33.98;389.16±57.53 vs243.45±62.31;P<0.001)]。以LVMI为因变量的多元逐步回归分析显示,影响因素为年龄、SBP、MMP-3、MMP-9和TIMP-1(r2=0.78,P<0.001)。高血压组按LVMI分为高血压合并左心室肥厚组(A组)、高血压无左心室肥厚组(B组),A组SBP、MMP-3、MMP-9和TIMP-1升高[(178±31 vs 166±25);(490.14±99.13 vs 405.56±53.12);(340.56±43.21 vs 290.15±33.98);(393.45±47.69vs 301.58±39.57);P<0.05]。结论血清MMP-3、MMP-9和TIMP-1水平是高血压合并左心室肥厚的影响因素。 Objective To investigate the relationship of matrix metalloproteinases (MMP-3 and MMP-9) and the tissue inhibitor TIMP-1 with left ventricular hypertrophy (LVH) in patients with primary hypertension. Methods Totally 140 patients with primary hypertension and 132 healthy controls were included. Matrix metalloproteinase - 3 (MMP- 3 ) , matrix metalloproteinase - 9 (MMP- 9) and tissue inhibitor metalloproteinase - 1 ( TIMP- 1 ) were measured. All subjects were taken echecardiography examination, then left ventrieular mass index ( LVMI ) was calculated. Results MMP-3, MMP-9, TIMP- 1 (488.32±100.32 vs 314.59±99.78 ; 340.56±43.21 vs 290.15±33.98 ; 389.16±57.53 vs 243.45±62.31 ; P 〈0.001 ) and LVMI ( 113.7±9.9 vs 88.3±10.4, P 〈 0.001 ) in patients with primary hypertension were significandy higher than those in controls. In a mu/tiple stepwise regression analysis with LVMI as the variable, it was found that age, SBP, MMP-3, MMP-9 and TIMP- 1 were main determinants for LVMI (r^2 =0.78, P 〈 0.001 ). 3. Patients with primary hypertension were divided into two subgroups according to LVMI, i.e., hypertension with LVH (group A) and hypertension without LVH (group B). SBP, MMP-3, MMP-9 and TIMP-1 ( 178±31 vs 166±25 ;490.14±99.13 vs 405.56±53.12; 340.56±43.21 vs 290.15±33.98 ; 393.45±47.69 vs 301.58±39.57 ; P 〈 0.05 ) of group A were significantly higher than those of group B. Conclusion MMP-3, MMP-9 and TIMP- 1 are influencing factors for LVH in patients with primary hypertension.
出处 《中国医科大学学报》 CAS CSCD 北大核心 2015年第6期485-488,共4页 Journal of China Medical University
基金 国家自然科学基金(81203002)
关键词 原发性高血压 基质金属蛋白酶3 基质金属蛋白酶9 金属蛋白酶组织抑制因1 左心室肥厚 primary hypertension matrix metalloproteinase-3 matrix metalloproteinase-9 tissue inhibitor metalloproteinase-1 left ventricular hypertrophy
  • 相关文献

参考文献17

  • 1刘力生.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8):701-708. 被引量:6934
  • 2Vendecchia P,Schillaci G,Borgioni C.Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive patients with normal left ventricular mass[J] .J Am Coll Cardiol,1995,25(4):871-878.
  • 3王文,张维忠,孙宁玲,林金秀,陈鲁原,吴可贵,朱鼎良,吴兆苏,刘力生.中国血压测量指南[J].中华高血压杂志,2011,19(12):1101-1115. 被引量:534
  • 4Heymans S,Schroen B,Vermeersch P,et al.Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart[J].Circulation,2005,112(8)&#x02236;1136-1144.
  • 5Ahmed SH,Clark LL,Pennington WR,et al.Matrix metalloproteinases tissue inhibitors of metalloproteinases:relationship between changes in proteolytic determinants of matrix composition and Structural,functional,and clinical manifestations of hypertensive heart disease[J].Circulation,2006,113( 17):2089-2096.
  • 6Zile MR,Brutsaert DL.New concepts in diastolic dysfunction and diastolic heart failure:Part l:diagnosis,prognosis,and measurements of diastolic function[J].Circulation,2002,105(11):1387-1393.
  • 7Lemarie CA,Tharaux PL,Lehoux S.Extracellular matrix alterations in hypertensive vascular remodeling [J].J Mol Cell Cardiol,2010,48(3):433-439.
  • 8Castro MM,Tanus -Santos JE,Gerlach RF .Matrix metalloproteinases targets for doxycycline to prevent the vascular alterations of hypertension[J].Pharmacol Res,2011,64(6):567-572.
  • 9雷莹,于晓玲,陈杭,许红.高血压病患者脉压指数与血管内皮功能相关性分析[J].中国医科大学学报,2011,40(3):255-258. 被引量:25
  • 10邵也常,邓木兰,连子斌,石美玲,江夏杏.广州农村人口基质金属蛋白酶3基因型分布特点及其与血压的关系[J].南方医科大学学报,2013,33(4):586-589. 被引量:3

二级参考文献100

共引文献7330

同被引文献43

引证文献4

二级引证文献36

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部