温润辛金培脾法治疗支气管哮喘合并变应性鼻炎的疗效分析

Efficacy Analysis of Warming and Moisturizing Lung with Supplementing Spleen for the Patients Suffering from Bronchial Asthma with Allergic Rhinitis

目的：探讨温润辛金培脾法对支气管哮喘合并变应性鼻炎的疗效及安全性。方法：选取支气管哮喘合并变应性鼻炎患者90例,进入意向性分析（Intention-to-treat,ITT）90例,进入符合方案数据分析（Per-protocol population,PP）86例。口服温润辛金培脾中药颗粒剂,10 g/次,每日3次。3周为1疗程,观察2疗程。对比患者治疗前后症状评分、肺功能指标、嗜酸粒细胞（EOS）、嗜酸粒细胞阳离子蛋白（ECP）、Ig E。结果：患者症状评分、肺功能指标、嗜酸粒细胞（EOS）、嗜酸粒细胞阳离子蛋白（ECP）、Ig E均显著改善（P〈0.05或P〈0.01）,差异有统计学意义。且无不良反应发生。结论：＂温润辛金培脾＂法治疗支气管哮喘合并变应性鼻炎（肺脾两虚型）疗效可靠,安全性高。

Objective： To observe clinical efficacy and security of warming and moisturizing lung with supplementing spleen for the patients with bronchial asthma and allergic rhinitis. Methods ：90 cases of bronchial asthma with allergic rhi- nitis patients ,90 cases were intentional analysis （ITF）and 86 cases were for project data analysis （PP）. Taking traditional Chinese medicine granules of warming and moisturizing lung with supplementing spleen orally, 10 g/time,3 times a day. A course of treatment was 3 weeks, observing the curative effect after 2 courses. Symptom score, pulmonary function, eosino- philic granulocyte（EOS）, eosinophil cationic protein （ECP）, IgE before and after treatment were be contrasted. Results： Symptom score, pulmonary function, EOS, ECP, IgE marked improvement significantly （ P 〈 0.05 or P 〈 0. 01 ） with statistical significance. And no adverse reaction occurred. Conclusion：To the patients suffering from bronchial asthma with allergic rhi- nitis, the curative effect of warming and moisturizing lung with supplementing spleen is reliable and secure.