结直肠癌与肠道菌群关系的研究进展

Progress on the relationship between colorectal cancer and intestinal flora

人体肠道微生态系统在健康状态下具有维持肠道正常结构,促进肠道对营养物质的消化吸收,抵抗病原微生物的侵入及调节肠道免疫应答等重要功能。有研究表明肠道菌群结构或数目的改变与结直肠癌的发生发展密切相关。了解肠道菌群参与结直肠癌发生的机制,有助于指导临床对结直肠癌患者的治疗及做好预防工作。目前肠道菌群在结肠癌中的具体发病机制仍不明确,本文将肠道菌群在结直肠癌发生发展中的菌群结构变化和致病机制最新研究进展进行综述。

The human gut micro ecology system in health state plays the roles of maintaining the normal structure, promoting the intestinal digestion and absorption of nutrients, resisting the invasion of pathogenic microor- ganism, regulating the intestinal immune response. Studies have shown that the change of structure or number of intes- tinal flora is closely related to the occurrence of colorectal cancer development. To understand the mechanism of intes- tinal flora in colorectal cancer can help to guide the clinical treatment of colorectal cancer patients and to do a good job of prevention. But the intestinal flora in the colon specific pathogenesis is still unclear. This article will review latest research progress of gut flora in its flora structure change in the development of colorectal cancer and pathogenic mechanisms.