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EZH2与肿瘤相关性研究进展 被引量：8

Research progress in correlation between EZH2 genes and tumors
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摘要 Zeste基因增强子人类同源物2(EZH2)基因作为多梳基因(Pc G)家族中的核心成员,其在多种实体肿瘤中过度表达并与肿瘤的发生、发展、转移等生物学行为及预后有着密切的关系,但其具体机制仍知之甚少。笔者对EZH2作用机制的最新研究进展进行综述,其对揭示肿瘤发生发展过程,预测肿瘤的进展及预后,进而开发新的肿瘤靶向治疗药物具有较大的潜在临床价值。 As a core member of polycomb group genes family, Ebgabcer of zeste homolog 2 （EZH2） is over-expressed in many solid tumors and is closely related to carcinogenesis and deterioration, metastasis and prognosis of tumor. However, how EZH2 promotes tumor is still poorly understood. This review presents the concrete mechanisms and the correlation between EZH2 and tumor, which has great potential clinical value in predicting the development and the prognosis of tumor, and developing new molecular therapeutic target for cancer.
作者 范晨宇 赵建农 朱蔚林
机构地区 南华大学 海南省人民医院神经外科
出处 《海南医学》 CAS 2015年第10期1469-1471,共3页 Hainan Medical Journal
基金 海南省自然科学基金(编号:309096)
关键词 Zeste基因增强子人类同源物2 侵袭性 转移 Ebgabcer of zeste homolog 2 （EZH2） Invasion Metastasis
分类号 R733 [医药卫生—肿瘤]
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参考文献23

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二级参考文献56

共引文献36

同被引文献67

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引证文献8

二级引证文献9

海南医学
2015年 第10期

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