食管胃结合部腺癌的研究进展

Progress in Research of Adenocarcinoma of Esophagogastric Junction

目的总结近年来食管胃结合部腺癌的研究进展,提高对该肿瘤的进一步认识,寻找更加合理、有效的治疗策略。方法采用文献复习的方法,对食管胃结合部腺癌研究相关的国内外文献加以综述。结果食管胃结合部腺癌在解剖、生理、病理等方面存在特殊性,与胃其他部位的肿瘤存在明显差异,对食管胃结合部腺癌的定义、生物学来源、分型、淋巴结转移等方面的研究已基本达成共识,但对于外科治疗的手术路径、切除范围、淋巴结清扫、消化道重建方式等问题长期以来各学派意见不一。结论食管胃结合部腺癌作为一类独立的疾病,对人类健康危害增加,目前最有效的治疗手段为手术切除,如何选择手术方式,需要深入研究。

Objective To summarize the current advancement of adenocarcinoma of the esophagogastric junction （AEG） and improve the knowledge and cognition about AEG and find a feasible treatment strategy. Method Relevant literatures about current advancement of AEG published domestically and abroad recently were collected and reviewed. Results AEG had obvious differences from other parts of stomach tumors in anatomy, physiology, and pathology. The study of AEG in definition, biology origin, classification, lymph node metastasis and other aspects had basically reached a consensus. But for the surgical approach, the extent of resection, lymph node dissection or the way of the digestive tract reconstruction was controversial for a long time. Conclusions AEG as a kind of independent disease is increasing hazard to human health. By far, the most effective treatment is surgical resection, and how to choose the surgical method needs to be further researched.