Notch1的异常激活与T细胞型急性淋巴细胞白血病

Abnormal activation of Notch1 and T-cell acute lymphoblastic leukemia

Notch1受体的异常激活在T细胞型急性淋巴细胞白血病(T-ALL)的发病中起主导作用。近期研究表明,超过60%的T-ALL患者中存在Notch1的激活性突变。文章简要介绍Notch1异常激活在T-ALL发病中的作用,以及针对Notch1异常激活的现有方法及其面临的问题,为T-ALL的研究及靶向治疗提供参考。

Abnormal activation of Notchl plays pivotal roles in the molecular pathogenesis of human T-cell acute lymphoblastic leukemia （T-ALL）. Activating Notchl mutations present in over 60% of the T-ALL patients. However, so far, there is no therapy with little side effects that specifically targets the abnormally activated Notchl pathway-induced T-ALL. The present study briefly reviewed the effects of abnormal activation of Notchl in the pathogenesis of T-ALL, as well as the current approaches targeting Notchl and its limitations, thus providing some guidance for the research and development of clinical therapies targeting T-ALL.