妊娠糖尿病母亲血清视黄醇结合蛋白4水平与巨大儿发生率的相关性研究

Study on the correlation between serum RBP4,GDM and the the incidence of macrosomia

目的:探讨妊娠糖尿病(GDM)母亲血清视黄醇结合蛋白4(RBP4)水平与巨大儿(MS)发生率的相关性。方法:随机选取2011年6月至2014年7月在我院住院的500例产妇,其中46例GDM产妇(研究组),分娩巨大儿(体重>4000g)16例,正常体重儿30例;糖耐量正常(NGT)产妇454例(对照组),分娩巨大儿37例,正常体重儿417例。采用ELISA法检测患者血清RBP4水平。分析RBP4与GDM及巨大儿发生率之间的相关性。结果:研究组的巨大儿发生率高于对照组26.7%,差异有统计学意义(P<0.05)。研究组正常体重儿产妇及对照组巨大儿产妇血清RBP4水平均高于对照组正常儿产妇,差异有统计学意义(P<0.05);研究组中巨大儿产妇的血清RBP4水平高于正常体重儿产妇,差异有统计学意义(P<0.05)。血清RBP4水平是分娩巨大儿的危险因素,呈正相关(P=0.000)。结论:GDM巨大儿发生率高于正常产妇;RBP4是巨大儿发生率高的影响因素之一,与巨大儿发生率呈正相关关系。

Objective：To explore the relationship between gestational diabetes mellitus （GDM）,serum retinol binding protein 4 （RBP4） and macrosomia （MS）. Methods：46 cases of GDM maternal were selected as the observation group,16 cases with macrosomia （ weight〉4000g） and 30 cases with normal children. 454 cases of normal glucose tolerance （NGT） were selected as the control group,37 cases with macrosomia and 417 cases with normal children. The level of RBP4 was tested by using ELISA method. The correlation between GDM and RBP4 of macrosomia was found out by using statistical method. Results：The macrosomia incidence of the GDM group was significant higher than that of the NGT group（P〈0. 05）. The mean level of serum RBP4 of the pregnant women with macrosomia was higher than that of the pregnant women with normal newborns,with significant difference（P〈0. 05）. There was a positive corre-lation between the RBP4 and the weight of newborns（P〈0. 05）. Conclusion：GDM has a great influence on the incidence of macrosomia. There is a positive correlation between RBP4 and the incidence of macrosomia.