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DEK蛋白和肿瘤关系的研究进展 被引量：7

Research advances in the correlation between DEK protein and oncogenesis
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摘要 DEK是多细胞生物细胞内含量丰富的可磷酸化的核蛋白,序列高度保守且无其他亚型。DEK主要在增殖活跃的细胞和癌细胞中高表达。最早在急性髓性白血病的一个亚型中以DEK-CAN融合蛋白的形式被发现,近年报道表明DEK在人类肿瘤中具有重要作用。多种恶性肿瘤如肝细胞癌、胶质母细胞瘤、视网膜母细胞瘤、膀胱癌、恶性黑色素瘤和宫颈癌中均有过表达。DEK是一种促进肿瘤细胞生长、浸润的染色质调节蛋白。本综述结合最新进展对DEK和肿瘤的关系作了全面的综述。 DEK protein is an abundant chromatin protein in metazoans with highly conserved nuclear factor. This protein is a unique member of its family and is preferentially expressed in actively proliferating and malignant cells. Recently, much attention has been paid to the role of DEK protein in the development of various cancers, which was originally discovered in a subset of acute my-elogenous leukemia. Oncogene DEK is overexpressed in several malignancies including hepatocellular carcinoma, glioblastoma, retino-blastoma, bladder cancer, malignant melanoma, and cervical cancer. Oncogene DEK is a chromatin remodeling protein that supports cancer cell proliferation and invasion. In this review, we summarized research advancements in the correlation between DEK protein and oncogenesis.
作者 刘光明 马洪顺
机构地区 天津市第一中心医院泌尿外
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2015年第9期482-486,共5页 Chinese Journal of Clinical Oncology
关键词 肿瘤 分子诊断 靶向治疗 DEK DEK tumor molecular diagnosis targeted therapy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献31

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二级参考文献50

  • 1吕自力,文剑明,罗殿中,张文敏,肖刚,张萌.肿瘤相关基因在肝细胞癌及癌旁正常肝组织中表达[J].临床与实验病理学杂志,2004,20(6):654-658. 被引量：4
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共引文献6

同被引文献34

  • 1周铮.DEK与肺癌发生发展机制的研究进展[J].中国实用内科杂志,2013,33(S1):159-163. 被引量：3
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引证文献7

二级引证文献9

中国肿瘤临床
2015年 第9期

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