1.5T 1H-MRS在正常胰腺中的应用

Application of 1.5T 1 H-MRS in normal pancreas

目的:探讨1.5T氢质子磁共振波谱成像(MRS)在活体正常胰腺中的应用价值及影响因素。方法:采用单体素点分辨波谱(PRESS)序列采集20例健康志愿者的正常胰腺波谱,分析脂质峰高(Lip)、峰下面积、脂质峰下面积(Lip)/组织内水峰下面积(InW)比值与年龄、身高体重指数(BMI)的相关性,分析胆固醇和不饱和脂肪酸的混合峰下面积(Chol+UnSat)/脂质峰下面积(Lip)比值与年龄、BMI的相关性。结果:1.5T活体胰腺MRS扫描成功率为90%(18/20)。Lip峰、TMA峰和Chol+UnSat混合峰显示率分别为100.0%(18/18)、89%(16/18)和100%(18/18)。Lip峰高与年龄、BMI呈正相关(r=0.715、0.356),有统计学意义(P=0.01、0.047),峰下面积与年龄、BMI呈正相关(r=0.503、0.135),与年龄有统计学意义(P=0.033),与BMI无统计学意义(P=0.593)。Lip/InW比值与年龄、BMI呈正相关(r=0.718、0.563),有统计学意义(P=0.01、0.015)。(Chol+Unsat)/Lip比值与年龄、BMI呈正相关(r=0.762、0.520),有统计学意义(P=0.000、0.027)。Chol+Unsat峰下面积与年龄、BMI呈正相关(r=0.519、0.466),有统计学意义(P=0.004、0.000)。结论:1.5T磁共振波谱成像能够用于检测正常活体胰腺的主要代谢物并分析其谱线形态。

Objective： To explore the application value and efficacy factors of 1.5T proton magnetic resonance spectroscopic imaging （MRS） of normal pancreas in vivo. Methods： Single voxel point resolved spectroscopy （PRESS） sequence was used to acquire the spectrum of normal pancreas in 20 healthy volunteers. The peak height of lipids （Lip）,area underneath peak and the ratio of area under the peak of lipid （Lip） with the area under peak of water within tissue （InW） and the ratio correlation with age and body mass index （BMI） were analyzed. Furthermore, the ratio of area under the mixed peak of cholesterol and unsaturated fatty acids （Chol＋UnSat） with the area under the peak Lip and its correlation with age and BMI were analyzed. Results.. The success rate of 1.5T 1 H-MRS scanning of the normal pancreas in vivo was 90%. The rates of displaying Lip peak,TMA peak and Cholq-UnSat mixed peak were 100.0% （18/18） ,89% （16/18） and 100% （18/18）, respectively. Positive correlations between the amplitude of Lip peak with the age and BMI were existed （r= 0. 715 and 0. 356）,with significant statistic difference （P= 0.01 and 0. 047）. There was significant positive correlations between the area underneath the peak of Lip with the age and BMI （r=0. 503 and 0. 135）,significant statistic difference with the age was existed （P= 0. 033）, yet there was no statistical difference with BMI （P= 0. 593）. There were significant positive correlations between Lip/InW with age and BMI （r=0. 718 and 0. 563） with statistic differences （P= 0.01 and 0. 015）, respectively. There were significant positive correlations between （Chol q-Unsat）/Lip with age and BMI （r = 0. 762 and 0. 520,P=0. 000 and 0. 027）, respectively. Significant positive correlations were existed between the area underneath the peak of （Cholq- Unsat） with the age and BMI （r= 0. 519 and 0. 466,P= 0. 004 and 0. 000） ,respectively. Conclusion： 1.5T 1H-MRS can be used to detect the major metabolites of normal pancreas in vivo, also the spectral morphology could be analyzed.