期刊文献+

青年人血浆高敏C反应蛋白水平对远期动脉僵硬度的预测价值 被引量:1

Predictive value of plasma high-sensitivity C-reactive protein for long-term arterial stiffness in young adults
原文传递
导出
摘要 目的探讨青年人群血浆高敏C反应蛋白(hsCRP)水平与远期动脉僵硬度的关系。方法研究队列共包括231名青年个体,基线期(2005年)年龄中位数为28岁,2013年对其进行随访。基线期和随访期均进行了一般信息采集,血压、身高、心率等人体测量及空腹血糖、血脂、hsCRP等生化指标测定,并于2013年使用无创自动波形分析仪测量臂踝动脉脉搏波传导速度(baPWV)。结果人群基线期和随访期血浆hsCRP水平分别为0.36(0.18-0.72)和0.50(0.22-1.05)mg/L。2005年hsCRP和2013年hsCRP间的相关系数为0.290(P〈0.01),校正混杂因素后,二者相关性未发生显著变化(r=0.186,P〈0.01)。 Objeetive To explore the relationship between long-term arterial stiffness and plasma high-sensitivity C reactive protein (hsCRP) in young adults. Methods This cohort comprised 231 young adults with the median age of 28 years at baseline in 2005, and they were followed up in 2013. Data at baseline and follow-up including general characteristics, blood pressure, height, heart rate, and biochemistry indexes such as fasting glucose, blood lipid, plasma hsCRP were collected Or measured. Brachial-ankle pulse wave velocity (baPWV) was recorded by noninvasire automatic waveform analyzer in 2013. Results Plasma hsCRP levels were 0.36 ( 0.18 - 0.72) and 0.50 (0.22-1.05) mg/L at baseline and follow-up, respectively. Correlation coefficient for plasma hsCRP was 0. 290 (P〈0.01) between 2005 and 2013, and did not exhibit material change after adjusting for confounders (r= 0. 186, P〈0.01 ). Adults with hsCRP ≥75 % interquantile point at baseline experienced a significantly high risk of being in the top quartile at follow-up (RR = 3. 321, 95% CI 1. 681 - 6. 559, P〈0.01 ) as compared with those with hsCRP〈75% interquantile point. Spearman correlation analysis indicated that baPWV was positively correlated with hsCRP at baseline and follow-up (both P〈0.05). After adjusting for age, sex, blood pressure and other confounders, plasma hsCRP was independently correlated with baPWV at follow-up (β= 0. 146, P= 0. 012) but not at baseline (β= -0. 028, P=0. 641) in stepwise multivariate regression analyses. After excluding adults who had hy- pertension or diabetes mellitus, plasma hsCRP was still an independent predicting factor for baPWV at follow-up (β=0. 157, P=0. 025) but not at baseline (β=0. 013, P=0. 853). Conclusion Although plasma hsCRP is an independent risk factor for baPWV within the same period, it cannot independently predict the long-term baPWV at early stage in young adults.
出处 《中华高血压杂志》 CAS CSCD 北大核心 2015年第4期337-342,共6页 Chinese Journal of Hypertension
关键词 高敏C反应蛋白 臂踝动脉脉搏波传导速度 动脉硬化 青年 High sensitivity C reactive protein Brachial-ankle pulse wave velocity Atherosclerosis Young adults
  • 相关文献

参考文献27

  • 1Mancia G. De Backer G, Dominiczak A, et al. 2007 ESH-ESC practice guidelines for the management of arterial hypertension: ESH-ESC task force on the management of arterial hypertension [J]. J Hypertens,2007.25(9) . 1751-1762.
  • 2Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham heart study [J]. Circulation,2010,121 (4) z505-511.
  • 3Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of car- diovascular events and all-cause mortality with arterial stiffness. a systematic review and meta-analysis[J]. J Am Coil Cardiol,2010, 55(13) :1318 1327.
  • 4Kim JS, Kang TS, Kim JB, et al. Significant association of C-re active protein with arterial stiffness in treated non-diabetic hyper- tensive patients[J]. Atherosclerosis, 2007,192(2) : 401-406.
  • 5Nagano M, Nakamura M, Sato K, et al. Association between se- rum C-reactive protein levels and pulse wave velocity: a popula- tion-based cross-sectional study in a general population [J]. Atherosclerosis, 2005,180(1) : 189-195.
  • 6Mattace-Raso FU, van der Cammen TJ, van der Meer IM, et al. C-reactive protein and arterial stiffness in older adults: the Rot- terdam study[J]. Atherosclerosis,2004,176(1) :111-116.
  • 7Qian J, Cai M, Gao J, et al. Trends in smoking and quitting in China from 1993 to 2003: national health service survey data[J]. Bull World Health Organ, 2010,88(10) : 769-776.
  • 8World Health Organization. International guide for monitoring al cohol consumption and related harm[M: Geneva: Department of Mental Health and Substance Dependence,WHO. 2000.
  • 9Davis PH, Dawson JD, Riley WA, et al. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: the Muscatine study [J]. Circulation,2001,104(23) :2815-2819.
  • 10Li S, Chen W, Srinivasan SR, et al. Childhood blood pressure as a predictor of arterial stiffness in young adults. the Bogalusa heart study[J]. Hypertension, 2004,43 (3) : 541-546.

二级参考文献25

  • 1刘治全,李玉明,牟建军,杨鼎颐,徐祥麟,王祥庆,杨军,胡继新.盐敏感性高血压与钠代谢及盐负荷后的肾排钠反应[J].中华心血管病杂志,1994,22(6):418-421. 被引量:22
  • 2刘治全,牟建军,徐祥麟,李玉明,王祥庆,胡继新,杨鼎颐.血胰岛素水平及盐敏感性与青少年高血压[J].中国高血压杂志,1995,3(1):23-25. 被引量:9
  • 3牟建军,杨军,刘治全,任洁,刘卫民,浦晓梅,徐祥麟,熊素娥.超重对青少年远期血压变化的影响[J].中华高血压杂志,2007,15(8):633-636. 被引量:25
  • 4Mancia G, De Backer G, Dominiczak A, et al. 2007 guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)[J]. Eur Heart J,2007,28(12):1462-1536.
  • 5Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham heart study [ J ]. Circulation, 2010,121 (4): 505-511.
  • 6Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of car- diovascular events and all-cause mortality with arterial stiffness: a systematic review and recta-analysis[J]. J Am Coll Cardiol,2010, 55(13): 1318-1327.
  • 7Li S, Chen W, Srinivasan SR, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Boga- lusa heart study[J]. JAMA,2003,290(17) :2271-2276.
  • 8Morrison JA, Glueck CJ, Wang P. Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabe- tes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-lipid research clinics follow-up study [J]. Metabolism,2012,61(4) :531-541.
  • 9Cavalcante JL, Lima JA, Redheuil A, et al. Aortic stiffness: current understanding and future directions [J ]. J Am Coll Cardiol,2011,57(14) : 1511-1522.
  • 10Santos PC, Alvim RO, Ferreira NE, et al. Ethnicity and arterial stiffness in Brazil[J]. Am J Hypertens.2011,24(3):278-284.

共引文献6

同被引文献11

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部