Kupffer细胞与肝脏移植的研究进展

Kupffer cells and liver transplantation

肝移植被公认为目前治疗终末期肝病最有效的手段,但术后缺血再灌注损伤(ischemiareperfusion injury,I/RI)及急慢性免疫排斥反应(immune rejection response,IRR)仍是影响预后及生存率的重要因素,遗憾的是,目前临床上的对症方案效果差强人意,且在当前供体紧缺的背景下,探索改善肝脏移植术后I/RI及急慢性IRR的有效方法,具有重要的临床意义.Kupffer细胞(Kupffer cells,KCs)是定居于肝脏的体内最大的抗原呈递细胞群,作为肝内第一防线,在移植后I/RI及IRR中具有多样性效能,但其在影响肝移植术后的病理进展中的具体机制目前尚未完全明了,故此将我们的研究发现及目前最新的研究结果做一综述.

Nowadays, liver transplantation is globally considered the most effective treatment for end-stage liver diseases. Ischemia-reperfusion （I/R） injury and immune rejection response （IRR） are the two major imperfections which severely affect the recipients＇ prognosis and survival rate without satisfactory clinical management strategies. Therefore, exploring effective methods to improve I/R injury and IRR have important clinical significance under circumstances of shortage of donor livers. Kupffer cells （KCs） are the largest population of antigen representing cells （APCs） which settle in the liver. As the first defensive line of the live, KCs exhibit various biological effects. However, the exact mechanisms responsible for the role of KCs in I/R injury and IRR remain elusive. We hereby review the current finding about the role of KCs in I/R injury and IRR.