宁夏回族自治区回、汉族食管胃交界部腺癌临床病理特征对比分析1524例

Clinical and pathological characteristics of adenocarcinoma of the esophagogastric junction in Hui and Han patients from Ningxia Hui Autonomous Region: Analysis of 1524 cases

目的:探究1524例回汉族食管胃交界部腺癌(adenocarcinoma of esophagogastric junction,AEG)患者的临床病理特征.方法:选择2002-01/2012-12于宁夏医科大学总医院住院治疗,经胃镜和病理证实的1524例AEG患者为研究对象,收集整理包括性别、年龄、血型、烟酒嗜好、病理分化及TNM分期等指标,输入Excel表格,建立数据库.采用SPSS17.0统计分析回汉族患者间各指标差异是否存在统计学意义.结果:1524例AEG患者中回族273例(17.9%),汉族1251例(82.1%),回汉族AEG患者间在年龄构成差异无统计学意义(x2=0.668,P=0.716),两组患者年龄均以>60岁为主;回汉族AEG患者间性别构成无统计学意义(x2=0.313,P=0.622),两组患者均以男性为主;回汉族AEG患者间ABO血型、家族史分布皆无统计学意义(x2=2.995,P=0.392;x2=0.222,P=0.894);两组AEG患者有吸烟、饮酒史者分布差异有统计学意义(x2=32.221,P<0.0001;x2=34.176,P<0.0001);虽然回汉族AEG患者间病理类型和TNM分期分布差异无明显统计学意义,不过两组间皆以低分化腺癌主(51.0%,50.2%),TNM分期以Ⅳ期主(49.1%,48.2%).结论:回汉族AEG患者间在年龄构成、性别、A B O血型、家族史、病理类型以及T N M分期方面无明显差异.回汉族A E G患者皆好发于老年男性,有吸烟饮酒史者;病理类型以低分化腺癌多见,TNM分期Ⅳ期多见.合理健康的生活方式以及早诊早治是预防AEG发生以及改善预后的有效途径.

AIM： To explore the clinical and pathological characteristics of adenocarcinoma of the esophagogastric junction （AEG） in 1524 cases of Hui and Han patients. METHODS： A total of 1524 patients confirmed to have AEG by gastroscopy and pathology at the General Hospital of Ningxia Medical University from January 2002 to December 2012 were involved. Relevant data including gender, age, blood type, alcohol addiction, pathological differentiation, and TNM stage were collected and input into Excel spreadsheet. SPSS17.0 software was used to perform statistical analysis. RESULTS： Among 1524 AEG cases, 273 （17.9%） were Hui patients and 1251 （82.1%） were Han patients. There was no significant difference between Hui and Han patients in age （X2= 0.668, P = 0.716）. Most patients in the two groups were older than 60 years.There was no significant difference between Hui and Han patients in gender （X2 = 0.313, P = 0.622）, and most patients in the two groups were males. There were no significant differences between Hui and Han patients in ABO blood type or family medical history （X2 = 2.995, P = 0.392; ;（2 = 0.222, P= 0.894）. There was a significant difference between the two groups in smoking and drinking history （X2 = 32.221, P 〈 0.0001; ;（2 = 34.176, P 〈 0.0001）. Although there was no significant difference between the two groups in pathological type or TNM stage （X2 = 8.221, P = 0.084; 2 = 1.162, P = 0.762）, the main pathological differentiation type in the two groups was lowly differentiated adenocarcinoma, and TNM stage was mainly IV. CONCLUSION： There were no significant differences between the two groups in age, gender, ABO blood type, family medical history, pathological type, or TNM stage. AEG has a higher incidence in older males who have smoking and drinking history. Main pathological type was lowly differentiated adenocarcinoma, and TNM stage was mainly IV. Early diagnosis and treatment as well as healthy and rational lifestyle may be helpful in the prevention and treatment of AEG.