利水健脾解毒汤灌肠联合酪酸梭菌活菌散治疗婴幼儿轮状病毒肠炎疗效观察

Lishui Jianpi Jiedu Decoction enema combined with Clostridium butyricum powder in treatment of Rotavirus Enteritis in Infants: efficacy observation

目的探讨利水健脾解毒汤灌肠联合酪酸梭菌活菌散口服治疗婴幼儿轮状病毒肠炎的临床疗效。方法将82例的患轮状病毒肠炎婴幼儿随机分为治疗组42例与对照组40例,两组患儿均给予常规治疗,治疗组给予利水健脾解毒汤灌肠及酪酸梭菌活菌散口服,对照组静滴利巴韦林,观察患儿治疗一疗程(3 d)临床疗效和轮状病毒转阴率。结果治疗组总有效率为90.47%,轮状病毒转阴率为71.43%,对照组分别为52.50%、32.50%。治疗组总有效率及轮状病毒转阴率均显著高于对照组(P<0.01),2组患儿均未出现不良反应。结论利水健脾解毒汤灌肠及酪酸梭菌活菌散口服治疗婴幼儿轮状毒肠炎疗效显著,安全性高,是治疗婴幼儿轮状病毒肠炎的有效方法。

Objective To observe the efficacy of lishui jianpi jiedu decoction （＂ Decoction＂, traditional Chinese herbal prescription having effects of diuresis promotion, spleen invigoration and detoxification ） enema combined with Clostridium butyricum powder in the treatment of Rotavirus Enteritis in infants. Methods 82 infants with Ro- tavirus Enteritis were randomly divided into two groups, 42 infants in treatment group and 40 infants in control group. Both groups were given conventional treatments; the treatment group was additionally given the Decoction enema and oral Clostridium butyricum powder while the control group was given iv infusion of ribavirin. The clinical efficacy and negative conversion rates after one course of treatment （3 days） were observed. Results In treatment group, the total efficacy rate was 90. 47%, and the negative conversion rate was 71.43%. In control group, the total efficacy rate was 52. 50% , and the negative conversion rate was 32. 5%. The differences were statistically sig- nificant （P 〈 0.01 ）. No adverse reactions occurred in both groups. Conclusion The Lishui Jianpi Jiedu Decoc- tion enema combined with Clostridium hutyricum powder is a safe and effective method for treatment of rotavirus en- teritis in infants.