2004-2013年广西壮族自治区大化瑶族自治县狂犬病疫苗免疫接种效果分析

Rabies vaccine immunization′s effect analysis in Dahua Yao Autonomous County,Guangxi Zhuang Autonomous Region from 2004 to 2013

目的了解少数民族自治县受伤居民接种狂犬病疫苗后的效果。方法对广西壮族自治区大化瑶族自治县2004-2013年狂犬病疫苗免疫接种者的资料及实验室抗体检测数据进行统计分析。结果该县2004-2013年对当地5 286名接受过狂犬病疫苗免疫接种的居民进行了抗体检测,抗体阳性者5 230名,阳性率为98.94%;抗体阴性者56名。40岁以上者接种狂犬病疫苗后抗体阳性率随年龄增加而下降。狂犬病疫苗传统接种程序（5针次）与改良接种程序（4针次）抗体阳性率[分别为99.89%（4 476/4 481）、97.69%（422/432）]比较,差异有统计学意义（χ^2=62.84,P〈0.05）。结论狂犬病疫苗免疫接种后效果监测十分重要,对免疫接种后抗体阴性者应及时加强补种疫苗。

Objective To know the effect of rabies vaccine inoculated by injured residents in minority autonomous county. Methods Rabies vaccine inoculators＇ data and laboratory antibody test data in Dahua Yao Autonomous County,Guangxi Zhuang Autonomous Region from 2004 to 2013 were statistically analyzed. Results Conducted antibody detection on 5286 residents who inoculated rabies vaccine in this county from 2004 to 2014. There were 5230 antibody positive cases and the positive rate was 98.94%. There were 56 antibody negative cases. The antibody positive rate of patients over 40 after inoculated rabies vaccine reduced as the age increased. Compared the antibody positive rate of traditional 5-time inoculation procedure with reformed 4- time inoculation procedure [respectively were 99.89% （4 476/4 481 ）,97.69% （422/432）],differences showing statistical significance （Х^2=62.84,P〈0.05）. Conclusion Minitoring the effect after inoculating rabies vaccine is very important. Reinoculate rabies vaccine if patients are antibody negative.