摘要
目的探讨孟鲁司特钠咀嚼片联合糠酸莫米松鼻喷雾剂治疗儿童过敏性鼻炎的临床疗效。方法选择2013年10月—2014年5月在重庆市中医院就诊的过敏性鼻炎患儿96例,随机分为对照组和治疗组,每组48例。对照组患儿使用糠酸莫米松鼻喷雾剂,每侧鼻孔100μg/次,1次/d。治疗组患儿在对照组的治疗基础上口服孟鲁斯特钠咀嚼片,5 mg/次,1次/d。两组患儿均连续治疗14 d。观察两组的临床疗效,比较两组患者鼻炎总体症状、流涕、鼻痒、喷嚏、鼻塞等评分的变化,同时检测两组白细胞介素10(IL-10)、干扰素γ(IFN-γ)、IL-4、Ig E的变化。结果治疗后,对照组和治疗组的总有效率分别为87.5%、100.0%,两组总有效率比较差异有统计学意义(P<0.05)。治疗7、14 d两组患儿喷嚏、流涕、鼻塞、鼻痒评分、症状总评分均较治疗前显著降低,同组治疗前后差异有统计学意义(P<0.05);且治疗组的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿的IL-4、Ig E显著降低,IL-10、IFN-γ水平均有明显升高,同组治疗前后差异有统计学意义(P<0.05);但治疗组这些检测因子的改善程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论孟鲁司特钠咀嚼片联合糠酸莫米松鼻喷雾剂治疗儿童过敏性鼻炎具有较好的临床疗效,可有效降低症状评分,调节鼻炎相关因子水平,值得临床推广应用。
Objective To explore the clinical effect of Montelukast Sodium Chewable Tablets combined with Mometasone Furoate Aqueous Nasal Spray in treatment of allergic rhinitis of children.Methods The patients with allergic rhinitis (96 cases) of the Hospital of Traditional Chinese Medicine in Chongqing from October 2013 to May 2014 were randomly divided into control and treatment groups, and each group had 48 cases. The patients in the control group were given Mometasone Furoate Aqueous Nasal Spray, both nostril 100μg/time, once daily. The patients in the treatment group werepo administered with Montelukast Sodium Chewable Tablets on the basis of the treatment in the control group, 5 mg/time, once daily. Both groups were treated for 14 d. After treatment, the efficacy was evaluated, changes of rhinitis general symptoms, runny nose, nasal itching, sneezing, and nasal congestion scores in two groups were compared. At the same time, IL-10, IFN-γ, IL-4, and IgE in two groups were detected.Results After treatment, the total effective rate of control and treatment groups were 87.5% and 100.0%, respectively, and there were differences between two groups (P&lt; 0.05). General symptoms, runny nose, nasal itching, sneezing, and nasal congestion scores in two groups on the 7 and 14 d of treatment was significantly reduced, and the difference was statistically significant in the same group (P &lt; 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P &lt; 0.05). After treatment, IL-4 and IgE in two groups were significantly reduced, while IL-10 and IFN-γ were significantly increased, and the difference was statistically significant in the same group (P &lt; 0.05). The improvement of detection factor in the treatment group was better than those in the control group, and there were differences between two groups (P&lt; 0.05).Conclusion Montelukast Sodium Chewable Tablets combined with Mometasone Furoate Aqueous Nasal Spray has the good clinical effect in 〈br〉 treatment of allergic rhinitis of children, and can effectively reduce the symptom scores, while can adjust the rhinitis correlation factors, which is worth clinical promotion.
出处
《现代药物与临床》
CAS
2015年第4期425-428,共4页
Drugs & Clinic
关键词
孟鲁司特钠咀嚼片
糠酸莫米松鼻喷雾剂
过敏性鼻炎
Montelukast Sodium Chewable Tablets
Mometasone Furoate Aqueous Nasal Spray
allergic rhinitis