2012—2014年中山市陈星海医院鲍曼不动杆菌的分布及耐药性分析

Analysis on distribution and drug resistance of Acinetobacter baumannii in Zhongshan Chen-Xinghai Hospital from 2012 to 2014

目的研究中山市陈星海医院鲍曼不动杆菌的分布及耐药性,为合理用药提供参考。方法对2012—2014年中山市陈星海医院鲍曼不动杆菌的分布及耐药情况进行回顾性统计分析。结果共分离出461株鲍曼不动杆菌,其标本的主要来源为痰液,其次为分泌物和引流液。感染区分布主要为重症监护病房,其次为老年综合科和呼吸内科。鲍曼不动杆菌对头孢唑林、头孢替坦、磷霉素、厄他培南、美洛培南、氨苄西林、呋喃妥因、强力霉素的耐药性较强,对头孢哌酮/舒巴坦、阿米卡星和多黏菌素B的耐药性弱,而且鲍曼不动杆菌的耐药性逐年递增。结论鲍曼不动杆菌对多种抗菌药物具有较高的耐药性,应该加强其耐药性的监控,选择合适的药物进行治疗。对于感染的高危科室和高危部位,应重点防控。

Objective To study the distribution and drug resistance ofAcinetobacter baumannii in Zhongshan Chen-Xinghai Hospital, and provide reference for rational drug use.Methods The distribution and drug resistance ofA. baumannii in Zhongshan Chen-Xinghai Hospital from 2012 to 2014 were reviewed, retrospectively.ResultsTotally 461 strains of bacteria were isolated. The specimens were mainly obtained from the sputum. The minority was from secretions and drained fluid. The infections distributed widely in intensive care unit, followed by elderly general department and respiratory department. The resistance ofA. baumannii against cefazolin, cefotetan, fosfomycin, ertapenem, meropenem, ampicillin, macrodantin, and doxycycline was high. The resistance against cefoperazone/sulbactam, amikacin, and polymyxin B was low. And the drug resistance ofA.baumannii increased year by year. ConclusionA. baumanniihas higher resistance to many kinds of antibacterial drugs. The monitoring of drug resistance should be strengthened, and appropriate drugs should be chosen for treatment. High-risk departments and parts of infection should be focused on prevention and control.