垂体后叶素对感染性休克患者氧合功能的影响

The effect of pituitrin for oxygenation of septic shock

目的旨在探讨垂体后叶素（pituitrin）对感染性休克患者氧合功能的影响。方法对64例感染性休克患者在给予儿茶酚胺类药物提升血压基础上，随机分两组加用或不加用小剂量垂体后叶素（0．01～0．04u／h）治疗，比较两组间去甲肾上腺素剂量及氧合功能的差异。结果垂体后叶素组与对照组相比、前者去甲肾上腺素剂量减少（ug／min）（7．67±5．36、11．14±5．27，P=0．012），治疗24h后前者氧合（PaO2/FiO2，mmHg）功能改善，统计学上显著高于后者（329．85±77．53、239±86．04，P=0．026）。结论垂体后叶素可减少去甲肾上腺素剂量，改善氧合作用。

Objective To evaluate the clinical effect of pituitrin for oxygenation of septic shock. Methods 64 patients with septic shock were randomly divided into two groups in a equal number, the pituitrin group and the control group. The pituitrin group was given pituttrin 0.01-0.04u/h while the contral group was treated with dopamine and/or norepinephrine （NE）. Results The parameters of two groups were compared 24 hours after the treatment. NE dosage reflected low （ug/min）, （7.67±5.36, 11.14±5.27, P =0.012） prior to the treatment. After the treatment, the pituitrin group＇s oxygenation level improved significantly （PaO2/FiO2,mmHg）, （329.85±77.53, 239 ±86.04, P =0.026）. Conclusion Low-dose pituitrin combined with catecholamine is considered being effective in decreasing norephinephrine dosage and improving oxygenation level.