调强放射用于治疗局部晚期鼻咽癌的临床疗效及不良反应分析

CLINICAL EFFICACY AND ADVERSE REACTION OF IMRT IN THE TREATMENT OF NASOPHARYNGEAL CARCINOMA

目的观察分析对鼻咽癌患者进行调强放射治疗的临床疗效和不良反应情况。方法选取2013年5月—2014年6月于该院进行治疗的局部晚期鼻咽癌患者52例为研究对象,将患者随机分为观察组和对照组二组,其中给予对照组患者常规放射治疗,给予观察组患者调强放射治疗,比较二组患者治疗后的临床疗效和不良反应的发生情况。结果观察组患者的总缓解率（92.9%）、无瘤生存率（57.1%）、总生存率（89.3%）均显著高于对照组总缓解率（87.5%）、无瘤生存率（37.5%）、总生存率（70.8%）,二组差异显著,具有统计学意义（χ2=4.05~4.37,P〈0.05）。并且观察组的不良反应发生率也较对照组低。结论调强放射治疗法治疗鼻咽癌的临床效果显著,不良反应的发生率低,值得临床推广。

Objective To observe the efficacy and adverse reaction of analysis of situation of IMRT for nasopharyngeal carcinoma. Methods Totally 52 patients with locally advanced nasopharyngeal carcinoma were selected as subjects treated in author＇s hospital from May 2013 to June 2014. The patients were randomly divided into study group and control group, which were given to the patients in the control group conventional radiation therapy, patients in study group were given intensity modulated radiation therapy, and then the clinical curative effect and adverse reaction of two group patients were compared. Results The total remission rate of patients in the study group was （92.9%） , disease free survival rate （57.1%） , overall survival rate （89.3% ）, were significantly higher than that of the control group （87.5%） of total remission rate, diseasefree survival rate （37.5%）, overall survival （70.8% ）, with a statistically significant differences （ x2 = 4. 05-4.37,P〈0.05）. And the incidence of adverse reactions in the study group was lower than that of the control group. Conclusion IMRT for nasopharyngeal carcinoma is worth the clinical promotion with significant clinical effect and a low incidence of adverse reaction.