摘要
目的 探讨慢性心力衰竭患者炎症细胞因子超敏C反应蛋白(hs-CRP)、半乳凝集素-3(Galectin-3)、高敏肌钙蛋白T(hs-cTnT)、贫血的改变其相关性。方法 选取NYHA分级Ⅱ~Ⅳ级的患者110例,测定血清hs-CRP、Galectin-3、血红蛋白(Hb)、hs-cTnT、氨基末端脑钠肽前体(NT-proBNP)水平,心脏彩色B超观察心脏结构及功能。结果 心功能Ⅳ级组hs-CRP、Galectin-3、hs-cTnT及贫血的发生率高于Ⅱ、Ⅲ级组(〈0.05);心功能Ⅲ级组的发生率也高于Ⅱ级组(〈0.05)。相关性分析显示,hs-cTnT与Galectin-3、hs-CRP呈正相关,Hb与Galectin-3、hs-CRP呈负相关(〈0.01);分别对hs-cTnT和Hb做多元线性回归,在调整年龄、性别、NT-proBNP、NYHA分级、左室舒张末期内径(LVEDD)、射血分数(EF)、hs-CRP和Galectin-3共8个可能的影响因素后,Hb与Galectin-3呈负相关,hs-cTnT与hs-CRP呈正相关(〈0.05)。结论 随着心功能的恶化,Galectin-3、hs-CRP、hs-cTnT水平及贫血的发生率逐渐升高。慢性心力衰竭贫血和心肌损伤可能与心衰炎症相关。
[Objective] To investigate the changes of hypersensitive C-reactive protein (hs-CRP), galectin-3, hypersensitive cardiac troponin T (hs-cTnT) and anemia in patients with chronic heart failure (CHF) and their correlations. [Methods] One hundred and ten patients (NYHA ]I-IV) with CHF hospitalized in our department were selected. Levels of hs-CRP, galectin-3, hemoglobin (Hb), hs-cTnT and N-terminal pro- brain natriuretic peptide (NT-proBNP) were measured respectively in the three groups, and examinations such as echocardiography were used for observation of cardiac structure and function. [Results] Levels of hs-CRP, galectin-3, hs-cTnT and the incidence of anemia in the heart function level IV group were higher than those in the level II and m groups (P 〈 0.05), while these data in the level m group were higher than those in the level II group (P〈 0.05). There was a positive correlation between hs-cTnT and hs-CRP, and also hs- cTnT and galectin-3, while Hb was negatively correlated with hs-cTnT and galectin-3 (P 〈 0.01). Hs-cTnT and Hb were dealt through multiple linear regression separately After adjusting totally eight possible influence factors including age, gender, NT-proBNP, NYHA classification, left ventricular end-diastolic diameter (LVEDD), EF, hs-CRP and galectin-3, Hb was negatively correlated with galectin-3 while hs-cTnT was posi- tively correlated with hs-CRP (P〈 0.05). [Conclusions] The worse the cardiac function, the higher the levels of hs-CRP, galectin-3, hs-cTnT and the incidence of anemia. Anemia and myocardial injury are possibly related with inflammation in the chronic heart failure patients.
出处
《中国现代医学杂志》
CAS
北大核心
2015年第11期86-89,共4页
China Journal of Modern Medicine
关键词
超敏C反应蛋白
半乳凝集素-3
贫血
高敏肌钙蛋白T
慢性心力衰竭
hypersensitive C-reactive protein
galectin-3
anemia
high-sensitivity cardiac troponin T
chronic heart failure