阿司匹林对老年原发性血小板增多症血小板活化及血液流变学的影响

Influence of aspirin on platelet activation and blood rheology of senile patients with essential thrombocythemia

目的观察阿司匹林对老年原发性血小板增多症(ET)患者血小板活化标志CD62p、CD61及血液流变学的影响,探讨预防性应用阿司匹林减少老年ET血栓形成的可行性。方法将65例老年ET患者分为治疗组(阿司匹林+羟基脲治疗,35例)和对照组(羟基脲治疗,30例),观察各组治疗前后CD62p、CD61及血液流变学的变化。流式细胞术检测血小板表面CD62P、CD61水平,同时检测血液流变学各项指标。结果治疗后,治疗组血小板活化指标CD62P、CD61水平均显著下降;全血黏度(高、中、低切)、血浆黏度、红细胞沉压积下降,与对照组比较差异均有统计学意义(P<0.05)。结论阿司匹林能降低老年ET患者血小板活化及血黏度,可预防性使用以减少血栓形成。

[Objective] To investigate the influence of aspirin on CD62p, CD61 and blood theology of senile patients with essential thrombocythemia, and explore the possibility of preventative application of aspirin in senile patients with essential tbrombocythemia in order to reduce thrombosis. [Methods] Sixty-five senile patients with essential thrombocythemia were randomly divided into two groups： treatment group （preventative application of aspirin, 35 cases） and control group （30 cases）. Changes of CD62p, CD61 and blood rheology were observed before and after treatment. CD62p, CD61 and blood rheology were examined by flow cytometry. [Results] The levels of CD62p and CD61 in the treatment group decreased remarkably after treatment （P〈 0.05）. Total blood viscosity, plasma viscosity and platelet aggregation rate in the treatment group decreased significantly compared to those in the control group （P〈 0.05）. [Conclusion] Aspirin can reduce the levels of CD62p, CD61 and blood viscosity of senile patients with essential thrombocythemia. In order to reduce thrombosis, preventative application of aspirin is available in senile patients with essential thrombocythemia.