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脂肪细胞因子与糖尿病心肌病变 被引量:2

Adipokines and diabetic cardiomyopathy
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摘要 糖尿病心肌病变在病理上主要表现为心肌间质重构和心肌纤维化,其具体发病机制尚不明确,与糖代谢障碍、心肌微血管病变等有关.新近研究发现脂肪组织可分泌多种生物活性物质如apelin、网膜素、visfatin、chemerin等,这些脂肪因子可能通过影响肾素-血管紧张素系统、心肌胰岛素抵抗、心肌能量代谢及心肌血管内皮功能等途径直接或间接影响心肌纤维化过程,进而对糖尿病心肌病变产生作用. The remodeling and fibrosis of myocardial interstitial are main pathological manifestations of diabetic cardiomyopathy.The mechanism of diabetic cardiomyopathy is not clear,but may be related to disorder of glycometabolism,myocardial microvascular lesions and so on.Adipose tissue can secret many bioactive factors,such as apelin,omentin,visfatin,chemerin and so on.The effects of these adipokines on renin-angiotensin system,myocardial insulin resistance,cardiac energy metabolism and vascular endothelial function may directly or indirectly affect myocardial fibrosis,which then play roles in diabetic cardiomyopathy.
作者 冯玲 颜晓东
出处 《国际内分泌代谢杂志》 2015年第3期202-204,共3页 International Journal of Endocrinology and Metabolism
关键词 糖尿病心肌病变 脂肪细胞因子 心肌纤维化 Diabetic cardiomyopathy Adipokines Myocardial fibrosis
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参考文献22

  • 1Teupe C,Rosak C.Diabetic cardiomyopathy and diastolic heart failure-difficulties with relaxation[J].Diabetes Res Clin Pract, 2012,97(2) : 185-194.
  • 2Zeng H,He X, Hou X,et al.Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomy-opathy via upregulation of sirtuin3[J].Am J Physiol Heart Circ Physiol, 2014,306(4) : H585-597.
  • 3里宏晴,张志,焦慧,马清华.Apelin-13对糖尿病大鼠心肌纤维化的影响[J].解放军医学院学报,2013,34(6):621-624. 被引量:14
  • 4Falcio-Pires I, Gonalves N, Gavina C, et al.Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans:possible target for treatment?[J].Expert Opin Ther Targets, 2010,14(3) :231-241.
  • 5Siddiquee K,Hampton J,Khan S,et al.Apelin protects against angiotensin 1/-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production[J].J Hypertens, 2011,29(4) :724-731.
  • 6Pchejetski D, Foussal C, Alfarano C, et al.Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase l[J].Eur Heart J, 2012,33(18) :2360-2369.
  • 7Maya L,Villarreal FJ.Diagnostic approaches for diabetic car- diomyopathy and myocardial fibrosis[J].J Mol Cell Cardiol,2010, 48(3) : 524-529.
  • 8Foussal C,Lairez O,Calise D,et al.Activation of catalase by apelin prevents oxidative stress-llnked cardiac hypertrophy [J]. FEBS Lctt, 2010,584( 1 ) : 2363-2370.
  • 9Romacho T, Sfinchez-Ferrer CF, Peir6 C.Visfatin/Nampt: an adipo- kine with cardiovascular impaet[J].Mediators Inflamm,2013, 946427.
  • 10Huang Q,Guo Y,Zeng H,et al.Visfatin stimulates a cellular renin-angiotensin system in cultured rat mesangial cells [J]. Endocr Res, 2011.36(3) :93-100.

二级参考文献14

  • 1Aneja A,Tang WH,Bansilal S. Diabetic cardiomyopathy:insights into pathogenesis,diagnostic challenges,and therapeutic options[J].{H}American Journal of Medicine,2008,(09):748-757.
  • 2Maya L,Villarreal FJ. Diagnostic approaches for diabetic cardiomyopathy and myocardial fibrosis[J].{H}Journal of Molecular and Cellular Cardiology,2010,(03):524-529.
  • 3Harmancey R,Taegtmeyer H. The complexities of diabetic cardiomyopathy:lessons from patients and animal models[J].Curr Diab Rep,2008,(03):243-248.
  • 4Tatemoto K,Hosoya M,Habata Y. Isolation and characteriza-tion of a novel endogenous peptide ligand for the human APJ receptor[J].{H}Biochemical and Biophysical Research Communications,1998,(02):471-476.
  • 5Corvol P. Effect of apelin in cardiovascular system and water metabolism[J].{H}THERAPIE,2009,(04):233-239.
  • 6Xu J,Carretero OA,Lin CX. Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarction[J].{H}American Journal of Physiology Heart and Circulatory Physiology,2007,(03):H1900-H1907.
  • 7Quercioli A,Mach F,Montecucco F. Novel treatment strategy with direct renin inhibition against heart failure[J].{H}Panminerva Medica,2010,(01):41-51.
  • 8Van Linthout S,Seeland U,Riad A. Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy[J].{H}Basic Research in Cardiology,2008,(04):319-327.
  • 9Barnes G,Japp AG,Newby DE. Translational promise of the apelin--APJ system[J].{H}HEART,2010,(13):1011-1016.
  • 10Gavin YO,Crackower MA,Peter HB. The role of ACE2 in cardiovascular physiology[J].{H}Trends in Cardiovascular Medicine,2003,(03):93-101.

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