摘要
糖尿病心肌病变在病理上主要表现为心肌间质重构和心肌纤维化,其具体发病机制尚不明确,与糖代谢障碍、心肌微血管病变等有关.新近研究发现脂肪组织可分泌多种生物活性物质如apelin、网膜素、visfatin、chemerin等,这些脂肪因子可能通过影响肾素-血管紧张素系统、心肌胰岛素抵抗、心肌能量代谢及心肌血管内皮功能等途径直接或间接影响心肌纤维化过程,进而对糖尿病心肌病变产生作用.
The remodeling and fibrosis of myocardial interstitial are main pathological manifestations of diabetic cardiomyopathy.The mechanism of diabetic cardiomyopathy is not clear,but may be related to disorder of glycometabolism,myocardial microvascular lesions and so on.Adipose tissue can secret many bioactive factors,such as apelin,omentin,visfatin,chemerin and so on.The effects of these adipokines on renin-angiotensin system,myocardial insulin resistance,cardiac energy metabolism and vascular endothelial function may directly or indirectly affect myocardial fibrosis,which then play roles in diabetic cardiomyopathy.
出处
《国际内分泌代谢杂志》
2015年第3期202-204,共3页
International Journal of Endocrinology and Metabolism