神经节苷脂钠对中老年脑卒中患者神经功能预后的影响

Influence of ganglioside sodium on the prognosis of neurological function for middle-aged and elderly patients with cerebral apoplexy

目的探讨神经节苷脂钠对中老年脑卒中患者神经功能预后的影响。方法选取本院神经内科2012年7月-2013年6月收治的43例脑卒中患者作为对照组,给予常规综合疗法治疗。选取本院神经内科2013年7月-2014年6月收治的43例脑卒中患者作为研究组,在对照组的基础上给予神经节苷脂钠治疗。比较两组治疗前后的血流动力学指标、氧化应激状况及神经功能缺损评分。结果研究组治疗后15、30、60 d的神经功能缺损程度评分显著低于对照组,差异有统计学意义（P〈0.05）。研究组的临床总有效率为90.7%,显著高于对照组的62.8%,差异有统计学意义（P〈0.05）。结论神经节苷脂钠联合综合疗法治疗中老年脑卒中效果显著,能够促进神经功能修复,值得临床推广应用。

Objective To explore the influence of ganglioside sodium on the prognosis of neurological function for mid-dle-aged and elderly patients with cerebral apoplexy. Methods 43 patients with cerebral apoplexy in the department of neurology in our hospital from July 2012 to June 2013 were selected as the control group,which was given regular com-prehensive therapy.43 patients with cerebral apoplexy in the department of neurology in our hospital from July 2013 to June 2014 were selected as the research group,which was given ganglioside sodium on the basis of the control group. Hemodynamic index,oxidative stress status and the score of deficiency of neurological function before and after treat-ment in two groups was compared. Results The score of deficiency of neurological function at 15,30 and 60 days after treatment in the research group were lower than that in the control group,with significant difference （P〈0.05）.The total clinical effective rate in the research group was 90.7%,which was higher than 62.8% in the control group,with signifi-cant difference （P〈0.05）. Conclusion The effect of ganglioside sodium combined with comprehensive therapy in the treatment of cerebral apoplexy in middle-aged and elderly patient is significant,which can promote the recovery of neu-rological function,it is worthy of clinical promotion and application.