化疗联合中药治疗在结直肠癌术后的临床效果观察

Clinical effect observation of chemotherapy combined with Chinese herbs treatment after colorectal cancer surgery

目的观察化疗联合中药治疗在结直肠癌术后的临床效果。方法 2012年9月-2014年9月,将60例结直肠癌术后患者随机分为两组,中药组（30例）采用FOLFOX6化疗方案联合中药,对照组（30例）单纯FOLFOX6化疗方案。比较两组的中医证候疗效、中医症状积分、不良反应情况、血清癌胚抗原（CEA）和T细胞亚群。结果中药组、对照组的中医证候疗效总有效率分别为70.00%、26.67%,两组比较,差异有统计学意义（P〈0.05）;两组治疗后的中医症状积分分别为（8.36±3.81）、（15.40±4.90）分,两组比较,差异有统计学意义（P〈0.05）。两组不良反应发生情况的比较：中药组治疗后的RBC、PLT水平显著高于对照组（P〈0.05）;中药组治疗后的ALT、AST水平显著低于对照组（P〈0.05）;两组的消化道毒性和神经毒性反应情况差异有统计学意义（P〈0.05）。中药组治疗后的CD4＋较对照组明显升高,CD8＋明显减低（P〈0.05）。结论结直肠癌术后化疗联合中药可以有效改善化疗引起的不良反应（骨髓抑制、消化道毒性和神经毒性反应）,提高免疫力。

Objective To observe the clinical effect of chemotherapy combined with Chinese herbs treatment after col-orectal cancer surgery. Methods From Septemper 2012 to Septemper 2014,60 patients undergone colorectal cancer surgery were evenly divided into two groups,Chinese medicinal group （combination of FOLFOX6 chemotherapy regimen combined with Chinese herbs） and control group （only FOLFOX6 chemotherapy regimen）.The curative effect of TCM syndrome,TCM symptom score,adverse reaction,serum carcino-embryonic antigen （CEA） and T cell subset between two groups was compared respectively. Results The total effective rate of TCM syndrome in Chinese medicinal group and control group was 70.00%and 26.67%respectively,and there was a statistical difference between two groups （P〈0.05）.The TCM symptom score in two groups after treatment was （8.36±3.81） points and （15.40±4.90） points,and there was a sta-tistical difference between two groups （P〈0.05）.Comparision of adverse reaction between two groups：RBC,PLT level after treatment in Chinese medicinal group was obviously higher than that of control group respectively （P〈0.05）;ALT,AST lev-el after treatment in Chinese medicinal group was obviously lower than that of control group respectively （P〈0.05）;there was a statistical difference of gastrointestinal toxicity and neurotoxicity response between two groups （P〈0.05）.CD4＋was obviously increased while CD8＋was obviously decreased after treatment in Chinese medicinal group compared with con-trol group （P〈0.05）. Conclusion After colorectal cancer surgery,chemotherapy combined with Chinese herbs can effec-tively improve adverse reaction induded by chemotherapy （myelosuppression,gastrointestinal toxicity and neurotoxicity response） and immunity.