中重度支气管哮喘联合治疗前后肺功能及临床评价分析

Pulmonary Function and Clinical Evaluation of Moderate or Severe Asthma before and after Combination Therapy

目的：分析支气管哮喘联合治疗前后肺功能及症状评分的变化。方法：收集2013年5月-2014年5月笔者所在医院收治的80例中重度支气管哮喘患者临床资料,按照随机数字表法将患者分为治疗组与对照组,每组40例。观察组采用沙美特罗氟替卡松联合噻托溴铵治疗,对照组仅用沙美特罗氟替卡松治疗,分析两组患者治疗前后的肺功能变化。结果：观察组患者FVC、FVC%、FEV1、FEV1%、FEV1/FVC、FEF25~75等指标改善明显优于对照组,差异均有统计学意义（P〈0.05）。观察组症状评分明显优于对照组,差异有统计学意义（P〈0.05）。结论：沙美特罗氟替卡松联合噻托溴铵治疗支气管哮喘,有利于改善患者哮喘症状,促进肺功能恢复,提高患者生活质量。

Objective： To analyze the changes of pulmonary function and symptom score before and after combination therapy.Method： 80 cases of moderate or severe asthma in our hospital from May 2013 to May 2014 were collected.The patients were randomly divided into the treatment group and the control group, 40 cases in each group.The treatment group was treated by Salmeterol Fluticasone combined with Tiotropium, the control group was only treated with Salmeterol Fluticasone.Changes of pulmonary function of two groups were analyzed.Result： FVC, FVC%, FEV1, FEV1%, FEV1/FVC, FEF25-75 of the treatment group improved significantly better than those of the control group, the differences were statistically significant（P〈0.05）.The symptom score of the treatment group was significantly better than that of the control group, the difference was statistically significant（P〈0.05）.Conclusion： Salmeterol Fluticasone combined with Tiotropium in the treatment of asthma can help to improve asthma symptoms and promote the recovery of lung function, which can improve life quality of asthma patients.