采用超微粉碎提升散结镇痛胶囊活性成分溶出度的研究

Research on ultrafine grinding technology of improving dissolution rates of effective components in Sanjie Zhentong capsule

该实验主要研究了超微粉碎技术对散结镇痛胶囊活性成分溶出度的影响。运用普通粉碎和超微粉碎技术制备细粉和超微粉后充填胶囊,再将超微粉湿法制粒后充填胶囊,制得的散结镇痛胶囊用浆法测定药物的体外累积溶出度,比较3种胶囊溶出差异。结果显示细粉、超微粉、超微粉制粒制得胶囊的白藜芦醇体外溶出度分别为26.11%,63.27%,67.49%;龙血素B的体外溶出度分别为7.160%,20.29%,23.05%。超微粉制粒制得的散结镇痛胶囊溶出度最高。超微粉碎粒径D90为13.221μm,可以显著提高散结镇痛胶囊活性成分白藜芦醇和龙血素B的溶出度(P<0.01)。

The effects of ultrafine grinding on the dissolution rates of the effective components in Sanjie Zhentong capsule （SZC） were studied in this experiment. Fine and ultrafine powder of SZC intermediates were made by ordinary grinding and ultrafine grinding technology, and then granulated by wet granulation. SZC were prepared by fine powder, ultrafine powder and ultrafine granules, respectively. With resveratrol and loureirin B as investigated indexes, dissolution rates of the four intermediates in SZC were determined by cup method and HPLC. The dissolution rates of resveratrol in SZC prepared by fine powder, ultrafine powder and uhrafine granules were 26. 11%, 63.27%, 67. 49%, respectively; and the dissolution rates of loureirin B were 7. 160%, 20. 29%, 23.05%, respectively. The dissolution rate of resveratrol and loureirin B in SZC prepared by ultrafine granules was the best. D90 size of ultrafine grinding was 13.221 μm and could improve the dissolution rates of resveratrol and loureirin B in SZC.