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Complexin在囊泡运输中的作用 被引量：3

The Function of Complexin in Vesicle Transmission
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摘要 神经递质释放对维持生物体正常的生命活动有着重要的意义,它是由囊泡运输介导完成的.神经元细胞中囊泡运输涉及许多蛋白质间的相互作用,共同调控这一复杂的过程,可溶性小分子蛋白Complexin(Cpx)在这一过程中起着重要的作用,它同时具有抑制囊泡自发发放和促进囊泡诱发发放的功能.本文综合国内外近20年的研究,着重介绍了Cpx蛋白各部分结构域的功能,及其与一些囊泡分泌相关蛋白,如SNARE复合体、Synaptotagmin(Syt),间的相互作用机制及其最新进展. Neurotransmitter release is critical for maintaining normal organism function,it is mediated by the vesicle transportation.A bundle of proteins regulate the complicated neuronal vesicle transmission by interacting with each other.The small soluble protein Complexin（Cpx） plays an important role that can both inhibit spontaneous vesicle fusion and promote evoked Ca2＋-dependent neurotransmitter release.In this review,we highlight the recent advances in the function of each domain of Cpx and the mechanisms of interacting with other vesicle exocytosis associated proteins such as SNARE complex and synaptotagmin.
作者 李小红 龚吉红 林显光 阳小飞
机构地区 中南民族大学生物医学工程学院脑认知国家民委重点实验室膜离子通道与药物研发实验室
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2015年第5期403-409,共7页 Progress In Biochemistry and Biophysics
基金 国家自然科学基金资助项目(31300892)~~
关键词 囊泡运输 COMPLEXIN SNARE SYNAPTOTAGMIN vesicle transmission complexin SNARE synaptotagmin
分类号 Q7 [生物学—分子生物学]
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参考文献56

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同被引文献26

  • 1Zeng M, Zhou J. Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells [J]. Cellular Signalling, 2008, 20(4): 659-665.
  • 2Jahn R, Fasshauer D. Molecular machines governing exocytosis of synaptic vesicles[J]. Nature, 2012, 490(7419): 201-207.
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  • 4Hobson R J, Liu Q, Watanabe S, et al. Complexin maintains vesicles in the primed state in C. elegans[J]. Curr Biol, 2011, 21(2): 106-113.
  • 5Yang X, Cao P, SO dhof T C. Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes [J]. PNAS, 2013, 110 (51): 20777-20782.
  • 6Gutie'rrez-Marti n Y, Bustillo D, Goi mez-Villafuertes R, et al. P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells [J]. Journal of biological chemistry, 2011,286(13): 11370-11381.
  • 7Kaeser-Woo Y J, Yang X, Sv dhof T C.C-terminal complexin sequence is selectively required for clamping and priming but not for Ca^2+ triggering of synaptic exocytosis [J]. J Neurosci, 2012, 32 (8): 2877-2885.
  • 8Martin J A, Hu Z, Fenz K M, et al. Complexin has opposite effects on two modes of synaptic vesicle fusion [J]. Curr Biol, 2011, 21 (2): 97-105.
  • 9Thomas J, Melia Jr. Putting the clamps on membrane fusion: how complexin sets the stage for calcium-mediated exocytosis [J]. FEBS letters, 2007, 581(11): 2131-2139.
  • 10Chen X, Tomchick D R, Kovrigin E, et al. Three-dimensional structure of the complexin/SNARE complex[J]. Neuron, 2002, 33(3): 397-409.

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生物化学与生物物理进展
2015年 第5期

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