Treatment of diabetes with encapsulated pig islets: an update on current developments

胶囊猪胰岛移植治疗糖尿病:现况与进展（英文）

The potential use of al ogeneic islet transplantation in curing type 1 diabetes mel itus has been adequately demonstrated, but its large-scale application is limited by the short supply of donor islets and the need for sustained and heavy immunosuppressive therapy. Encapsulation of pig islets was therefore suggested with a view to providing a possible alternative source of islet grafts and avoiding chronic immunosuppression and associated adverse or toxic effects. Nevertheless, several vital elements should be taken into account before this therapy becomes a clinical reality, including cell sources, encapsulation approaches, and implantation sites. This paper provides a comprehensive review of xenotransplantation of encapsulated pig islets for the treatment of type 1 diabetes mel itus, including current re-search findings and suggestions for future studies.

本文对胶囊猪胰岛异种移植治疗糖尿病的相关研究进行综述,展示目前的研究现状,指出目前存在的问题,并提出未来的研究方向。基于包被胰岛的体积、活性、功能及生物安全性等重要决定因素,对猪胰岛来源、胶囊包被技术/方法及植入部位的选择进行了对比性、系统性地阐述,具有较高的参考价值。胶囊猪胰岛异种移植治疗糖尿病具有良好的应用前景,小胶囊或保形包被技术或是今后的发展方向。