未折叠蛋白反应对2型糖尿病发生发展的影响
摘要
未折叠蛋白反应(UPR)是内质网应激时胰岛β细胞启动一系列与蛋白质分泌相关的适应性反应,以恢复细胞内环境的稳态。但是,持久或剧烈的内质网应激,内质网稳态不能恢复,UPR信号由促进生存转为促进凋亡。由于胰岛β细胞的大量凋亡与2型糖尿病密切相关,故通过干预UPR治疗2型糖尿病正在受到越来越多的关注。
出处
《江苏医药》
CAS
2015年第9期1059-1061,共3页
Jiangsu Medical Journal
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