阔韧带Wolff管附件肿瘤的临床病理观察

Clinical and pathological observation of the broad ligament Wolffian adnexal tumor

目的探讨Wolffian管附件肿瘤(Wolfffian adnexal tumor,WAT)的临床病理学特征及免疫组化。方法对1例发生于阔韧带的WAT进行临床病理特征分析和免疫组织化学观察。结果肿瘤位于阔韧带,呈带蒂有包膜的囊实性肿块,组织学可见大小腺管紧密排列、筛状及实性区结构。免疫组织化学显示肿瘤细胞pan-cytokeratin、Vimentin、CK18、CD99阳性表达,alpha-inhibin灶性阳性;calretinin、CD10、EMA、ER、PR、Syn、CA15-3和CA19-9阴性,Ki-67指数小于5%。PAS染色腺样结构周围基底膜阳性。结论 WAT主要依靠病理组织学、免疫组化和具有特征性的wolffian管残件结构诊断。

Objective To explore the clinicopathological and immunohistochemical features of wolffian adnexal tumour （ WAT） . Meth-ods The clinical and pathological features analysis and immunohistochemistry methods were utilized to study the histopathology features of a case Wolffian adnexal tumor. Results One case of unilateral WAT which located in broad ligament display a solid-cystic mass with pedicled and enveloped,its histology showed large and small tubulars,screen structure and solid zone. Its immunohistochemistry staining was positive for pan-cytokeratin,vimentin,CK18 and CD99,positive staining for α-inhibin in a little tumor cell,and negative for calretinin,CD10,EMA, ER,PR,Syn,CA15-3,CA19-9,Ki-67 index is less than 5%. PAS positive staining for the basement membrane around Gland like structure. Conclusion Wolffian adnexal tumour is diagnosised by its histopathological,immunohistochemical and it’ s distinctive location where Wolffi-an duct remnants are found.