参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展

Advances in research on signal transduction mechanisms and their inhibitors for the proliferation of pulmonary artery smooth muscle cells

肺动脉高压是一种以肺血管阻力升高为特征,最终导致右心功能严重受限、衰竭甚至死亡的慢性进展性疾病。其组织病理学改变主要以肺血管重构为特点,而肺动脉平滑肌细胞在外周血管的异常增殖是肺血管重构的主要病理基础。该文主要对参与肺动脉平滑肌细胞增殖信号转导机制及信号转导抑制剂的研究进展作一综述。

Pulmonary artery hypertension （PAH ） is a chronic progressive disease characterized by a persistent elevation of pul-monary vascular pressure,and the disease would limit the right ventricular function severely,fail the organ and even lead to death in the end.The histopathological change of PAH is fea-tured by the restructuring of pulmonary vessels,and the abnor-mal reproduction of pulmonary artery smooth muscle cells （PASMCs）in peripheral vessels is the major pathological basis＆nbsp;of pulmonary vascular restructuring.This paper mainly reviews the research advances on signal transduction mechanisms and their inhibitors in promoting the proliferation of pulmonary artery smooth muscle cells.