清肺活血方联合阿奇霉素治疗难治性小儿支原体肺炎的平行对照研究

Treatment of Intractable Pediatric Mycoplasma Pneumonia by Qingfei Huoxue Recipe Combined Azithromycin: a Random Parallel Control Study

目的探究难治性小儿支原体肺炎在清肺活血方联合阿奇霉素治疗下患者临床治愈效果。方法将院内难治性小儿支原体肺炎患者124例纳入本次研究,并将其随机分为研究组和对照组,每组62例,研究组患者治疗选择清肺活血方联合阿奇霉素治疗方式,对照组患者仅采用阿奇霉素进行治疗,且所有本次研究对象均采用全方位系统护理。观测两组患儿疗效、临床治疗指标(具体为:咳嗽、啰音消失及体温恢复时间)及不良反应发生率。结果治疗后,治疗组有效率为91.94%(57/62);对照组有效率为77.42%(48/62),治疗组明显高于对照组,差异有统计学意义(P<0.05)。与对照组比较,治疗组咳嗽、啰音消失及体温恢复时间均明显缩短,差异有统计学意义(P<0.01)。治疗组不良反应发生率[3.23%(2/62)]明显低于对照组[38.71%(24/62)],差异有统计学意义(P<0.01)。结论对于难治性小儿支原体肺炎的临床治疗,中西医结合配合科学系统性护理方式优势更明显,疗效显著,值得推广应用。

Objective To explore the effect of Qingfei Huoxue Recipe （QHR） combined azithro- mycin in treatment of intractable pediatric mycoplasma pneumonia. Methods Totally 124 intractable pediatric mycoplasma pneumonia patients at our hospital were recruited in this study, and randomly assigned to the treatment group and the control group, 62 in each group. Patients in the control group took azithromycin, while those in the treatment group additionally took QHR. All patients received omnibearing systematic nursing. Therapeutic efficacy, clinical indices （such as disappearance time of cough and rales, recovery time of body temperature）, and the incidence of adverse reactions were observed. Results After treatment the total effective rate was 91.94% （57/62 cases） in the treatment group and 77.42% （48/62 cases） in the control group with statistical difference （P 〈0.05）. Compared with the con- trol group, disappearance time of cough and rales, recovery time of body temperature were obviously shortened in the treatment group with statistical difference （P 〈0.01 ）. There was statistical difference in the incidence of adverse reactions between the two groups [3.23% （2/62 cases） vs 38.71% （24/62 cases）, P 〈0.01]. Conclusion In clinical treatment for intractable pediatric mycoplasma pneumonia, Chinese medicine combined Western medicine plus scientific and systematic nursing showed more obvious advantages with significant efficacy, which was worth spreading. KEYWOIRDS integrative medicine; intractable pediatric mycoplasma pneumonia; Qingfei Huoxue Recipe