摘要
microRNA(miRNA)是一类内源性染色体上的非编码单链RNA,通过翻译抑制或降解靶mRNA在转录后水平调控基因表达。miRNA在发育、细胞分化、增殖、凋亡、病毒感染及癌变等多种病理、生理过程中起重要作用。miRNA直接参与肝癌的发生、发展,与肝癌的诊断、转移、预后和靶向治疗等相关。本文就近年miRNA与肝癌研究的新进展作一概述。
microRNAs are non-coding single stranded RNAs in endogenous chromosome that regulate gene expression post-transcritionally through degradation or inhibition translation of target mRNA. miRNAs play important roles in many pathologic functions, such as development, cell differentiation or proliferation, apoptosis, virus pathogenesis, and onco- genesis, miRNAs directly participate in the occurrence and development of hepatocellular carcinoma （HCC） and are as- sociated with the diagnosis, metastasis and prognosis of HCC. This review summarized new progress of the relationship between miRNAs and HCC.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第5期501-505,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
国家国际科技合作专项(2013DFA32150)
关键词
肝细胞癌
MICRORNA
诊断
转移
预后
Hepatocellular carcinoma
microRNA
Diagnosis
Metastasis
Prognosis
