代谢综合征组分对患者发生胃肠道溃疡的影响

The effect of metabolic syndrome components on gastrointestinal ulcers

目的探讨代谢综合征组分对患者发生胃肠道溃疡的影响。方法选取2013年5月-2014年7月在阳新县人民医院经过临床诊断确诊为胃肠道溃疡的患者52例作为病例组,并从同期健康人群中随机抽取健康体检者52名作为对照组。对所有受试者的腰围(WC)、体质量指数(BMI)、血压、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)进行测定,并对各代谢综合征组分与胃肠道溃疡的关系进行单因素分析和多因素回归分析。结果单因素分析结果显示WC≥88 cm、HDL-C<1.29 mmol/L、收缩压≥130 mm Hg和FBG≥5.6 mmol/L病例组较对照组发生胃肠道溃疡的危险性增加(OR=2.203、2.125、1.541、2.245);多因素分析结果显示病例组收缩压升高、FBG升高、HDL-C降低较对照组发生胃肠道溃疡的危险性增加(OR=2.768、1.782、2.024)。结论代谢综合征有增加胃肠道溃疡发生风险的趋势。

Objective To investigate the effect of metabolic syndrome components on gastrointestinal ulcers. Meth- ods Fifty-six cases of gastrointestinal ulcer diagnosed by clinic in the People＇ s Hospital of Yangxin County from May. 2013 to Jul. 2014 were collected as experimental group, and 52 cases of healthy controls were collected as the control group at the same time. Waist circumference （WC）, body mass index （BMI）, blood pressure, fasting blood glucose （FBG） , triglyceride （ TG）, total cholesterol （TC） , low-density lipoprotein cholesterol （ LDL-C）, high density lipopro- tein cholesterol （HDL-C） of all subjects were measured. The relationship between components of the metabolic syn- drome and gastrointestinal ulcer was analyzed by univariate analysis and multivariate regression analysis. Results Uni- variate analysis showed that WC ≥0.88 cm, HDL-C 〈 1.29 mmol/L, systolic blood pressure ≥ 130 mmHg and FBG ≥ 5.6 mmol/L in experimental group had higher gastrointestinal ulcers risk than control group （ OR = 2. 203,2. 125, 1. 541,2. 245）. Multivariate analysis showed that the incidence risk of gastrointestinal ulcers increased in experimental group with systolic blood pressure elevated, FBG elevated and HDL-C reduced （OR =2. 768,1. 782,2. 024）. Conclu- sion Metabolic syndrome increases the risk of gastrointestinal ulcers.