MFG-E8对肠黏膜保护作用的研究进展被引量：8

Progress of MFG-E8 for intestinal mucosa protection

下载PDF

导出

摘要乳脂肪球表皮生长因子8(milk fat globule epidermal growth factor 8,MFG-E8)作为一种细胞膜上的亲脂性糖蛋白,可能参与多种细胞间的相互作用,具有抗炎、促进巨噬细胞对凋亡细胞的吞噬、促进血管增生、促进黏膜修复等多种功能。MFG-E8也因此成为近几年的研究热点。在胃肠道疾病中,肠黏膜的损伤是溃疡性结肠炎、胰腺炎、克罗恩病等发生、发展的重要因素,阻断肠黏膜损伤、促进肠黏膜修复对疾病的治疗具有重要意义。近年来已有大量研究表明MFG-E8对于肠道黏膜损伤有明显的抗炎、促进肠黏膜修复的作用。本文就MFG-E8对肠黏膜保护作用的研究进展作一概述。 Milk fat globule epidermal growth factor 8 （MFG-E8） may participate in the interaction among various cells, has a variety of functions, such as anti-inflammatory, enhancing engulfment of apoptotic cells, promoting blood vessel growth and mucosal repair, and so on. In gastrointestinal diseases, intestinal mucosal injury is an important factor in the occurrence and development of ulcerative colitis, Crohn＇ s disease and pancreatitis. Blocking the intestine muco- sal injury and promoting the intestinal mucosal repair in treatment of diseases have important significance. Studies have shown that MFG-E8 has anti-inflammation and promoting the intestinal mucosal repair for intestinal mucosal injury. This review will summarize progress of MFG-E8 for intestinal mucosa protection.

作者陈丽向军英

机构地区川北医学院附属医院消化内科

出处《胃肠病学和肝病学杂志》 CAS 2015年第5期609-611,共3页 Chinese Journal of Gastroenterology and Hepatology

基金四川省卫生厅课题(130340)

关键词乳脂肪球表皮生长因子8 肠黏膜损伤肠黏膜修复 Milk fat globule epidermal growth factor 8 Intestinal mucosal injury Intestinal mueosal repair

分类号 R574 [医药卫生—消化系统]

引文网络
相关文献

参考文献25

1Stubbs JD, Lekutis C, Singer KL, et al. cDNA cloning of a mouse mam- mary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor V-like sequences [ J ]. Proc Natl Acad Sci U S A, 1990, 87(21) : 8417-8421.
2Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes [ J]. Nature, 2002, 417 (6885): 182-187.
3Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice [ J]. Sci- ence, 2004, 304(5674) : 1147-1150.
4Collins C, Nehlin JO, Stubbs JD, et al. Mapping of a newly discov- ered human gene homologous to the apoptosis associated-murine mam- mary protein, MFG-E8, to chromosome 15q25 [ J]. Genomics, 1997, 39(1): 117-118.
5Lin L, Huai Q, Huang M, et al. Crystal structure of the bovine lactad- herin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor V [J]. J Mol Biol, 2007, 371(3): 717-724.
6Liu Y, Yang X, Guo C, et al. Essential role of MFG-E8 for phagocytic properties of microglial cells [J]. PLoS One, 2013, 8(2) : e55754.
7Cui T, Miksa M, Wu R, et al. Milk fat globule epidermal growth fac- tor 8 attenuates aeute lung injury in mice after intestinal ischemia and reperfusion [ J ]. Am J Respir Crit Care Med, 2010, 181 ( 3 ) : 238 -246.
8Neher JJ, Emmrich JV, Fricker M, et al. Phagocytosis executes de- layed neuronal death after focal brain ischemia [ J ]. Proe Natl Aead Sei U S A, 2013, 110(43) : E4098-E4107.
9Matsuda A, Wu R, Jacob A, et al. Protective effect of milk fat glob-ule-epidermal growth factor-factor ]l after renal isehemia-repeffusion injury in mice [J]. Crit Care Med, 2011, 39(9) : 2039-2047.
10Lauber K, Keppeler H, Munoz LE, et al. Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorti- colds [J]. Cell Death Differ, 2013, 20(9) : 1230-1240.