LCZ696在慢性心力衰竭中的研究进展

Research progress of LCZ696 in chronic heart failure

慢性心力衰竭(CHF)是大多数心血管疾病的最终归宿,且因具有高发病率、高死亡率而引起人们的关注。LCZ696具有抑制肾素-血管紧张素-醛固酮系统(RASS)和脑啡肽酶的双重作用,成为CHF的一种新治疗方法。本文总结归纳了LCZ696在治疗CHF中的作用及相关机制,并对LCZ696作为一种治疗CHF的新药在前期临床试验中的结果进行简单介绍。

Summary Chronic heart failure （CHF） is the end result of various cardiovascular diseases. It has caused much concern because of its high morbidity and mortality. LCZ696 has dual effect on inhibition of the renin angio- tensin aldosterone system （RASS） and the neprilysin, and becomes a new drug for the treatment of CHF. The present review primarily focuses on the related mechanisms of LCZ696 in the treatment of CHF,and makes a brief summary of LCZ696 on its outcomes in preclinical trials as a new drug for CHF.