ATP结合盒转运子A1基因M883I多态性与动脉粥样硬化易感性的相关性分析

Meta-analysis:relationship between ATP-binding cassette transporters A1 M883I polymorphism with susceptibility to atherosclerosis

目的：研究ATP结合盒转运体A1（ABCAl）基因M883I多态性与动脉粥样硬化（AS）的相关性。方法：计算机检索CNKI、万方数据库、VIP及Medline、PubMed、Web of Science数据库,收集中国人群ABCAl基因M833I多态性与AS相关性的病例对照研究或队列研究,检索时间从建库至2014年4月30号。在评价纳入研究质量并提取有效数据后,用Stata12.0软件进行meta分析,计算OR值及95%CI,并评价分析结果的可靠性与稳定性。结果：16篇文献最终纳入研究,累积AS患者4 985例,对照人群14 286例。森林图显示,在高加索人群中,病例组M等位基因频率显著高于I等位基因（OR：0.87,95%CI：0.78～0.96,P〈0.05）,而在亚洲人群中,中国汉族人群（OR：1.05,95%CI：0.79～1.41,P〉0.05）以及其他民族人群M等位基因较I等位基因（OR：1.15,95%CI：0.99～1.33,P〉0.05）均没有显著性差异。结论：在高加索人群中,ABCAl基因M883I位点多态性与AS的发生有显著相关性,而与亚洲人群AS的发生则没有相关性。

Objective：To evaluate the association of ABCA1 gene M883I polymorphism with the susceptibility to atherosclerosis （AS）. Method： Relative literatures were fully searched and screened from CNKI, Wanfang, VIP, Medline, PubMed and Web of Science before April 30, 2014. The pooled OR and its 95%CI were calculated, and the evaluation of the reliability and stability of the results were performed through meta-analysis by Statal2.0 software. Result：Sixteen literatures containing 4 985 cases and 14 286 controls were included, results from meta-analysis showed that significant association were observed between the ABCA1 gene M883I polymorphism and AS in the population of Caucasians （OR： 0. 87, 95%CI： 0. 78--0.96, P〈0.05）, but there was no significant correlation in the Asians, neither in Chinese Han population （OR ： 1.05, 95% CI ： 0.79-- 1.41, P〈0.05）, nor in other ethnic groups （OR： 1.15, 95%CI： 0. 99--1.33, P〈0.05） . Conclusion：There is no correlation between M883I polymorphism at the ABCA1 gene and atherosclerosis in Chinese Han population as well as other ethnic groups in Asia, but a significant correlation in Caucasians.