摘要
目的:探讨最大颈动脉内膜中层厚度(cIMT)及颈动脉斑块对冠心病(coronary heart disease,CHD)的诊断预测作用。方法:将无CHD史的214例患者经冠状动脉(冠脉)CT或冠脉造影证实冠脉狭窄≥50%分为CHD组82例和无CHD组132例。记录一般情况、入院血压及血脂数据,测量最大cIMT以及记录颈动脉斑块位置。结果:CHD组中最大cIMT明显大于无CHD组,差异有统计学意义[(1.09±0.20)∶(0.99±0.20),P〈0.01]。CHD组颈总动脉斑块和颈动脉窦斑块发生概率与无CHD组相比有显著增加(P〈0.01)。而两组的颈内动脉斑块发生概率则无显著差异。将入组的CHD危险因素、最大cIMT及颈动脉斑块进行logistic回归后退法分析,发现高血压(OR=3.052,95%CI1.671~5.782,P〈0.01)和颈总动脉斑块(OR=2.757,95%CI1.283~5.924,P〈0.01)、颈动脉窦斑块(OR=2.635,95%CI1.425~4.873,P〈0.01)与CHD的发生明显相关,是CHD的强预测因素。结论:颈总动脉斑块及颈动脉窦斑块是CHD的强预测因素,可作为临床辅助预测CHD的简便、无创、有效的诊断预测指标。
Objective:The purpose of this study was to evaluate the value of maximum carotid intima-media thickness (cIMT) and carotid plaques for predicting coronary artery disease (CHD). Method: Two hundred and fourteen patients with no history of coronary heart disease underwent computed tomography angiography or coro- nary angiography. And then divided into CHD group (n=82) and non-CHD group (n= 132) which due to coro- nary artery stenosis≥50% ,measured blood pressure and blood fat, and measured maximum clMT and recorded the position of carotid plaques. Result=Maximum eIMT was significantly higher in CHD group than which in non- CHD group(1.09=1=0.20 vs 0. 99±0. 20,P〈0. 01). The incidence of plaque in common carotid artery(CCA) and carotid blub(CB) in CHD group were significantly increased than non-CHD group (P〈0.01). But there was no significant difference in internal carotid artery(ICA). Multiple logistic regression backward analysis reveals that hypertension (OR=3.052,95%CI 1. 671- 5. 782, P〈0. 01) and CCA plaque (OR=2.757,95%CI 1.283 5.924,P〈0.01),CB plaque (OR=2. 655,95% CI 1. 42544. 875,P〈0. 01) were associated with CHD,which were stronger predictor of CHD. Conclusion: CCA plaque and CB plaque were stronger predictor of CHD which could be used as a simple,noninvasive and useful marker for prediction of CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2015年第5期532-535,共4页
Journal of Clinical Cardiology
关键词
颈动脉内中膜厚度
颈动脉斑块
冠心病
carotid intima-media thickness
carotid artery plaque
coronary artery disease