血浆脑钠肽在非ST段抬高急性冠状动脉综合征危险分层中的临床意义

The clinical value of N-terminal natriuretic peptide in risk stratification for the patients with non-ST elevation acute coronary syndrome

目的:探讨非ST段抬高急性冠状动脉综合征(NSTE-ACS)患者血中N末端脑钠肽(NT-BNP)水平在危险分层中的意义。方法:入选81例患者,入院检查NT-BNP及肌钙蛋白I浓度(cTnI),依据GRACE评分标准对患者进行风险评估,计算积分,并进行危险分层,分为低危、中危、高危3组。分析NT-BNP与cTnI浓度及GRACE积分的关系;对比不同组别患者NT-BNP水平的差异。结果:NSTE-ACS患者NT-BNP与cTnI及GRACE积分呈正相关,并且低危、中危及高危组之间NT-BNP浓度有显著性差异(P<0.05)。结论:NSTE-ACS患者NT-BNP水平越高,GRACE积分越高,NT-BNP的检测对NSTE-ACS患者进行早期、快速的危险度分层方面有着独特的价值。

Objective：To explore the clinical value of N-terminal natriuretic peptide （NT-BNP） in risk stratifi- cation for patients with non-ST elevation acute coronary syndrome （NSTE-ACS）. Method： We enrolled 81 pa- tients with NSTE-ACS. In these patients, NT-BNP and cardiac troponin I （cTnI） concentration were tested. According to the GRACE score standard, all patients were stratified into threee groups. The relationship between NT-BNP level and GRACE risk score as welt as cTn I was analyzed. The difference of NT-BNP in three groups was compared. Result：The relationship between NT-BNP level and GRACE score as well as cTnI were positively correlated. The NT-BNP levels in three groups had significant differences （P^0.05）. Conclusion： In patients with NSTE-ACS, the higher NT-BNP concentration, the higher the GRACE scoreis, Measurement of NT-BNP is valuable for risk stratification in patients with NSTE-ACS.