白介素36α在结直肠癌中的表达及生存预测价值

Expression and prognostic significance of interleukin-36α in colorectal cancers

目的 探讨白介素36α（IL-36α）在结直肠癌患者中的表达及预后价值.方法 采用免疫组织化学法检测329例结直肠癌肿瘤组织中IL-36α的表达情况,根据IL-36α表达强度及阳性细胞比例,将患者分为IL-36α低表达组和IL-36α高表达组,比较两组患者的临床病理因素及其预后情况.结果 IL-36α低表达组和IL-36α高表达组在结直肠癌的分化程度和远处转移方面比较,差异有统计学意义（均P ＜0.05）.IL-36α低表达组和IL-36α高表达组患者的5年总生存率和无瘤生存率分别为79.3％、77.2％和66.3％、65.3％（均P＜0.05）.COX比例风险模型单因素及多因素分析结果显示,IL-36α高表达是影响结直肠癌患者总生存时间和无瘤生存时间的独立不良预后因素（均P ＜0.05）.结论 IL-36α与结直肠癌的分化程度和远处转移相关,并且是结直肠癌患者预后不良的独立影响因素.

Objective To investigate the expression and prognostic significance of Interleukin-36α （IL-36α） in colorectal cancer.Methods The expression of IL-36α was tested by immunohistochemical staining in 329 cases of colorectal cancer.According to the intensity and the proportion of positive tumor cells,all the patients were divided into IL-36α low and high expression groups.The clinicopathological factors and prognosis of patients between IL-36α low high expression groups were compared.Results Significant differences were observed in the number of patients in tumor differentiation and pM classification between patients in the IL-36α low and high expression groups （P 〈 0.05）.The 5-year overall and tumorfree survival rates of patients were 79.3% and 77.2% in IL-36α low expression group,and 66.3% and 65.3% in IL-36α high expression group （P 〈0.05）.COX proportional hazard regression model revealed that high expression of IL-36α was associated with short overall survival time and tumor-free survival time of colorectal cancer patients （P 〈 0.05）.Multivariate analysis identified IL-36α expression in colorectal cancer as an independent prognosticator （P 〈 0.05）.Conclusions High expression of IL-36α was correlated with tumor differentiation and pM classification of colorectal cancers,and it is an independent predictor of poor survival for patients with colorectal cancer.