胚胎着床中的分子机制研究进展

Advances in molecular mechanisms of embryo implantation

胚胎顺利着床是获得妊娠的关键环节,该过程蕴含着复杂的生物学分子机制。本文从子宫内膜因素和胚胎因素2个方面,归纳和总结了近年来关于胚胎着床时分子机制的研究进展。其中,肌节同源框基因1(muscle segment homeobox gene 1,Msx1)、转录因子库鲁普样因子5(kruppel like factor 5,Klf5)、节律调节基因和Sirt 1蛋白等分子介导的信号通路调节着子宫内膜的容受性。肝素结合EGF样生长因子(heparin binding EGF-like growth factor,HB-EGF)对发育停滞的胚胎具有潜在的保护作用,基因B3gnt5、Eomes、印记基因PHLDA、核因子E2相关因子2(nuclear factorE2-related factor 2,NRF2)等对胚胎自身发育、代谢、滋养层细胞功能的影响和抵抗外界不利环境的分子作用机制。

Embryo implantation is a key link of pregnancy. Complex and esoteric biological mechanisms are implicated in the process. This review includes xespects of the endometrial and embryonic molecular aspects of metabolic mechanisms of embryo implantation. Signaling pathways of muscle segment homeobox gene 1 （Msxl）, kruppel like factor 5 （Klf5）, circadian gene and Sirt 1 protein regulatate and control endometrial reception. heparin binding EGF-like growth factor （HB-EGF） plays a protective role to the embryo. B3gnt5 gene, Eomes gene, imprinted gene PHLDA and nuclear factor-E2-related factor 2 （NRF2） protein impact the embryo metabolism, function of trophoblast ceils and resistance to adverse environment.