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基质金属蛋白酶与颅脑损伤研究进展

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摘要 颅脑损伤（traumatic brain injury,TBI）病理反应包括直接损伤和继发性损伤,均可破坏神经血管单元（neurovascular unit,NVU）的结构和功能完整性[1],从而导致一系列的中枢神经系统（central nervoussystem,CNS）功能紊乱和结构变化。
作者 李庆勇 钱志远
机构地区 苏州大学附属第二医院神经外科
出处 《中国临床神经外科杂志》 2015年第5期312-314,共3页 Chinese Journal of Clinical Neurosurgery
关键词 颅脑损伤 基质金属蛋白酶 神经血管单元 血管再生 轴突再生
分类号 R651.15 [医药卫生—外科学]
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参考文献18

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  • 2Milward EA, Fitzsimmons C, Szklarczyk A, et al. The matrix metalloproteinases and CNS plasticity: an overview [J]. J Neuroimmunol, 2007, 187: 9-19.
  • 3Candelario-Jalil E, Yang Y, Rosenberg GA. Diverse roles of matrix metalloproteinases and tissue inhibitors of metallo- proteinases in neuroinflammation and cerebral ischemia [J]. Neuroscience, 2009, 158: 983-994.
  • 4Heo JH, Lucero J, Abumiya T, et al. Matrix metalloprotein- ases increase very early during experimental focal cerebral ischemia [J]. J Cereb Blood Flow Metab, 1999, 19(6): 624- 633.
  • 5Von Gertten C, Holmin S, Mathiesen T, et al. Increases in matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-I mRNA after cerebral contusion and depolarisation [J]. J Nenrosci Res, 2006, 73(6): 803-810.
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二级参考文献36

  • 1石向群,杨金升,张志琳,王运良,包仕尧.水通道蛋白4基因干预对大鼠脑缺血再灌注损伤后血脑屏障形态及功能的影响[J].中国临床康复,2004,8(31):6928-6930. 被引量：11
  • 2周杰,章翔,蒋晓帆,高大宽,常洪波,梁景文,宋蕾.大鼠脑创伤后小胶质细胞激活的时程及形态变化研究[J].中国临床神经外科杂志,2006,11(4):226-229. 被引量：9
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共引文献5

中国临床神经外科杂志
2015年 第5期

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