摘要
目的 观察心力衰竭伴肾功能不全患者心脏再同步化治疗(CRT)1年后心功能改善情况.方法 连续入选在我科住院的终末期心力衰竭伴肾功能不全患者36例,评估、测量患者术前、术后1年NYHA分级、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、血浆B型脑钠肽(BNP)和血浆肌酐浓度.结果 与术前相比,术后1年患者NYHA分级改善(2.5±0.4比3.6±0.3,P<0.05),LVEDD缩小[(60.5±6.3)mm比(72.4±6.7)mm,P<0.05],LVEF增大[(45.2±4.5)%比(27.1±6.6)%,P<0.05],血浆BNP浓度明显下降[(6094.0±2103.9)pg/ml比(12135.1±3897.1)pg/ml,P<0.05],血肌酐水平较前明显下降[(1.77±0.23) μg/ml比(2.49±0.36) μg/ml,P<0.05].结论 心脏再同步化治疗能改善心力衰竭伴肾功能不全患者的心脏功能.
Objective To evaluate the effects of cardiac resynchronization therapy in heart failure patients with renal insufficiency. Methods CRT was implanted in thirty-six heart failure patients with renal insufficiency, NYHA grade, left ventricular diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and B-type natriuretic peptides (BNP), serum creatinine(Cr) were evaluated before cardiac resynchronization therapy and one year later after cardiac resynchronization therapy. Results Compared to the results before cardiac resynchroniza- tion,one year later, NYHA grade was improved (3.6± 0.3 vs 2.5± 0.4,P〈0.05), LVEDD was smaller [(72.4± 6.7) mm vs (60.5± 6.3)mm, P〈O.05], LVEF increased [(27.1± 6.6)% vs (45.2± 4.5)%, P〈0.05], BNP decreased [(12135.1± 3897.1)pg/ml vs (6094.0+2103.9)pg/ml, P〈0.05], Cr also decreased significantly [(2.49± 0.36 )μg/ml vs (1.77±0.23)μg/ml, P〈0.05 ]. Conclusion Cardiac resynchronization therapy could improve left ventricular function of the heart failure patients with renal insufficiency.
出处
《中国心血管病研究》
CAS
2015年第5期414-416,共3页
Chinese Journal of Cardiovascular Research
关键词
心脏再同步化治疗
心功能
肾功能不全
B型脑钠肽
Cardiac resynchronization therapy
Left ventricular function
Renal insufficiency
B-type natriuretic peptides