高分辨磁共振对颅内动脉瘤壁成像的初步评估

A preliminary assessment of the intracranial aneurysm wall imaging with high-resolution magnetic resonance imaging

目的探讨高分辨磁共振(HR-MRI)管壁成像技术在颅内动脉瘤破裂风险评估中的可行性。方法回顾性分析2013年11月至2015年3月收治54例66个动脉瘤患者的3.0 T HR-MRI多序列管壁成像资料,比较其中49例未破裂颅内动脉瘤(UIA)瘤壁强化组(18例,21个动脉瘤)与未强化组(31例,40个动脉瘤)的动脉瘤病变特征,分析影响破裂的危险因素。将另外5例破裂动脉瘤作为对照组,按照动脉瘤大小、部位及临床基本特征以1∶2比例从UIA中选取基线匹配患者10例作为未破裂组,比较两组动脉瘤病变特征。结果 (1)HR-MRI显示瘤壁强化与否在不同动脉瘤的位置、瘤体大小、是否为宽颈动脉瘤、瘤高与颈宽比值的差异均无统计学意义(均P>0.05);(2)瘤体体率<2组与≥2组的强化率分别为20.0%(8/40)和61.9%(13/21),破裂组动脉瘤子囊发生率高于未破裂组,差异均有统计学意义(均P<0.05)。两组瘤颈宽度、瘤体体率、瘤高与颈宽比值和强化情况差异无统计学意义(均P>0.05)。结论研究初步结果显示,HR-MRI动脉瘤壁强化与动脉瘤破裂有相关的趋势,但需要进一步扩大样本随访研究。

Objective To investigate the feasibility of the arterial wall imaging technology of high-resolution magnetic resonance imaging （ HR-MRI） in the risk assessment of intracranial aneurysm rupture. Methods Fifty-four patients with 66 intracranial aneurysms underwent 3. 0 T HR-MRI multiple sequences arterial wall imaging from November 2013 to March 2015 were analyzed retrospectively. Five patients with ruptured aneurysm were used as a control group. The characteristic differences of aneurysm lesions between an unruptured intracranial aneurysm （ UIA） wall enhancement group and a non-enhancement group were compared. The risk factors for rupture were analyzed according to the size,location, and basic clinical characteristics of aneurysm. Results （1） HR-MRI revealed that whether the aneurysm walls enhanced or not,there were no significant differences in the location size,wide-necked aneurysm or not,and ratios of aneurysm height and neck width （all P 〉0. 05）. （2） The enhancement rates of the aneurysm volume 〈2 group and ≥2 group were 20%（8/40） and 61. 9%（13/21） respectively,the incidence of the ruptured aneurysm asci was higher than that of UIA,and there was significant difference （ all P〈0. 05）. There were no significant differences in neck width,rate of aneurysm volume,ratios of aneurysm height and neck width,and enhancement rates among the groups. Conclusion The preliminary results of this study have showed that there is a related trend between the HR-MRI aneurysm wall enhancement and the risk of rupture,but a further large sample follow-up study is needed.