过敏性紫癜性肾炎患儿血清异常糖基化免疫球蛋白A1水平变化

Changes in the level of serum abnormal glycosylated immunoglobulin A1 in children with Henoch-Schonlein purpura nephritis

目的探讨异常糖基化免疫球蛋白(Ig)A1与儿童过敏性紫癜性肾炎(HSPN)的关系。方法选择2013年3月至2014年5月在襄阳市第一人民医院接受治疗的过敏性紫癜(HSP)患儿40例(HSP组)和HSPN患儿20例(HSPN组),另选取同期体检健康儿童40例作为对照组;对各组儿童血清中炎症及免疫学相关指标进行比较。结果3组儿童血清白细胞、C反应蛋白、补体3、Ig M、Ig G水平比较差异均无统计学意义(P>0.05);HSP组和HSPN组患儿血清Ig A、Ig A1、异常糖基化Ig A1水平显著高于对照组(P<0.05),HSPN组患儿血清Ig A、Ig A1、异常糖基化Ig A1水平显著高于HSP组(P<0.05)。结论 HSPN患儿血清中异常糖基化Ig A1水平显著升高,异常糖基化Ig A1可能与HSPN的发生有关。

Objective To explore the relationship between abnormal glycosylated immunoglobulin（Ig） A1 and Henoch- Schonlein purpura nephritis （ HSPN ） in children. Methods Forty children with Henoch-Schonlein purpura （HSP） in HSP group and twenty children with HSPN in HSPN group in the First People＇s Hospital of Xiangyang City were selected from March 2013 to May 2014, and forty healthy children were selected as control group during the same time. The serum inflamma- tory and immunological indexes were compared among the groups. Results There was no significant difference in the levels of serum white blood cell, C-reactive protein, complement 3, IgM and IgG in the three groups （ P 〉 0.05 ）. The levels of serum IgA, IgA1 and abnormal glycosylated IgA1 in HSP group and HSPN group were significantly higher than those in control group （ P 〈 0. 05 ）. The levels of serum IgA, IgA1 and abnormal glycosylated IgA1 in HSPN group were significantly higher than those in HSP group （ P 〈 0.05 ）. Conclusions The level of sex-am abnormal glycosylated IgA1 in children with HSPN increases sig- nificantly. Abnormal glycosylated IgA1 may be related to the occurrence of HSPN.