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特利加压素治疗肝肾综合征疗效分析及不良反应研究 被引量:2

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摘要 目的观察特利加压素治疗肝肾综合征(HRS)的近远期疗效及不良反应。方法将42例患者随机分为两组:A 组22例为基础治疗联合特利加压素;B 组20例为基础治疗。观察治疗期间患者临床症状、尿量、肌酐、平均动脉压及血钠等指标。结果与 B 组比较,A 组患者治疗后临床症状明显改善,尿量增加(P <0.01),平均动脉压上升(P <0.01),血肌酐值下降(P <0.01),但两种治疗方案对血钠的影响差异无统计学意义(P >0.05)。A 组出现相关不良反应(房性期前收缩、痉挛性腹痛、水样泻等),而 B 组无明显不良反应发生。A 组患者生存期较 B 组明显延长(P <0.05),特别是Ⅱ型 HRS 患者的生存期延长更明显(P <0.01)。结论特利加压素治疗HRS 有明显的疗效优势,同时也有一定的不良反应,但通常发生的不良反应较为轻微,并且能较明显改善 HRS 患者的生存期。
出处 《临床内科杂志》 CAS 2015年第5期346-347,共2页 Journal of Clinical Internal Medicine
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