摘要
Aminopeptidase N （APN） is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe （Bes-Green, 2） that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells （ES-2） and has potential application in biological study of cellular APN.
Aminopeptidase N （APN） is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe （Bes-Green, 2） that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells （ES-2） and has potential application in biological study of cellular APN.
基金
supported by the Program for New Century Excellent Talents in University(No.NCET-11-0306)
the Shandong Natural Science Foundation(No.JQ201019)
the Independent Innovation Foundation of Shandong University, IIFSDU(No.2014JC008)
the Graduate Independent Innovation Foundation of Shandong University,GIIFSDU(No.yzcl2096)
